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William Jencks
William Platt Jencks (August 15, 1927 – January 3, 2007) was an American biochemist. He was noted particularly for his work on enzymes, using concepts drawn from organic chemistry to understand their mechanisms. Career Jencks graduated from Harvard College in 1947 with a degree in English, and earned a Doctor of Medicine from Harvard University in 1951. He interned at the Brigham and Women's Hospital, Peter Bent Brigham hospital. Jencks conducted his first postdoctoral research for two years with Fritz Lipmann at Harvard Medical School. Jencks was drafted into the Army Medical Corps and was assigned to the Army Medical Service Graduate School at Walter Reed Medical Center in Washington, DC. He worked with E. L. Durrum and served as the chair of the department of pharmacology. In 1956–1957, he did a second Public Health Service post-doctoral fellowship, postdoc with R. B. Woodward of the Harvard University Department of Chemistry. In 1957, he moved to the new graduate pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bar Harbor
Bar Harbor is a resort town on Mount Desert Island in Hancock County, Maine, United States. As of the 2020 census, its population is 5,089. During the summer and fall seasons, it is a popular tourist destination and, until a catastrophic fire in 1947, the town was a noted summer colony for the wealthy. The town is home to the College of the Atlantic, Jackson Laboratory and MDI Biological Laboratory. Bar Harbor is also home to the largest parts of Acadia National Park, including Cadillac Mountain, the highest point within of the coastline of the eastern United States. From the mainland, Bar Harbor is accessible by road via Maine State Route 3, by air at Hancock County–Bar Harbor Airport, and by ferry from Winter Harbor, Maine, and Yarmouth, Nova Scotia. History The town of Bar Harbor was founded on the northeast shore of Mount Desert Island, which the Wabanaki Indians knew as ''Pemetic'', meaning "range of mountains" or "mountains seen at a distance." The Wabanaki seas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Post-doctoral Fellowship
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marine Biological Laboratory
The Marine Biological Laboratory (MBL) is an international center for research and education in biological and environmental science. Founded in Woods Hole, Massachusetts, in 1888, the MBL is a private, nonprofit institution that was independent for most of its history, but became officially affiliated with the University of Chicago on July 1, 2013. It also collaborates with numerous other institutions. As of 2022, 60 Nobel Prize winners have been affiliated with MBL as students, faculty members or researchers. In addition since 1960, there have been, 137 Howard Hughes Medical Institute investigators, early career scientists, international researchers, and professors; 306 members of the National Academy of Sciences; and 236 Members of the American Academy of Arts and Sciences who have been affiliated with the lab. History 19th century The Marine Biological Laboratory grew from the vision of several Bostonians and Spencer Fullerton Baird, the United States' first Fish Commiss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Wald
George Wald (November 18, 1906 – April 12, 1997) was an American scientist who studied pigments in the retina. He won a share of the 1967 Nobel Prize in Physiology or Medicine with Haldan Keffer Hartline and Ragnar Granit. In 1970, Wald predicted that “civilization will end within 15 or 30 years unless immediate action is taken against problems facing mankind.” Research As a postdoctoral researcher, Wald discovered that vitamin A was a component of the retina. His further experiments showed that when the pigment rhodopsin was exposed to light, it yielded the protein opsin and a compound containing vitamin A. This suggested that vitamin A was essential in retinal function. In the 1950s, Wald and his colleagues used chemical methods to extract pigments from the retina. Then, using a spectrophotometer, they were able to measure the light absorbance of the pigments. Since the absorbance of light by retina pigments corresponds to the wavelengths that best activate pho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calvert School
Calvert School, founded in 1897, is an Independent school, independent, non-sectarian, co-educational lower and middle school located in Baltimore, Maryland. Calvert School is a member of the National Association of Independent Schools (NAIS) as well as the Association of Independent Maryland and DC Schools (AIMS). History Established in 1896 when four Baltimore families hired German school teacher Fraulein Martha Auguste Schurmann to conduct traditional kindergarten classes for their children, Calvert School continues to build upon the foundation laid by Fraulein Schurmann. The first children were taught above Croft and Conlin's drug store. In 1899, Calvert School hired its first Headmaster, Virgil M. Hillyer, a Harvard graduate. Calvert School's current Lower School on Tuscany Road was designed by Hillyer along with Laurence Hall Fowler. Hillyer insisted on larger windows so that rooms would be pleasant to children and let in light and air. His design included details suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Philosophical Society
The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and community outreach. Considered the first learned society in the United States, it has about 1,000 elected members, and by April 2020 had had only 5,710 members since its creation. Through research grants, published journals, the American Philosophical Society Museum, an extensive library, and regular meetings, the society supports a variety of disciplines in the humanities and the sciences. Philosophical Hall, now a museum, is just east of Independence Hall in Independence National Historical Park; it was designated a National Historic Landmark in 1965. History The Philosophical Society, as it was originally called, was founded in 1743 by Benjamin Franklin, James Alexander (lawyer), James Alexander, Francis Hopkinson, John Bartram, Philip Syn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Repligen Corporation Award In Chemistry Of Biological Processes
The Repligen Award in Chemistry of Biological Processes was established in 1985 and consists of a silver medal and honorarium. Its purpose is to acknowledge and encourage outstanding contributions to the understanding of the chemistry of biological processes, with particular emphasis on structure, function, and mechanism. The Award is administered by the Division of Biological Chemistry of the American Chemical Society. The award was suspended in 2018 until a patron can be found. Recipients SourceACS - Division of Biological Chemistry *1986 – Gregorio Weber *1987 – Thomas C. Bruice *1988 – Robert H. Abeles *1989 – Stephen J. Benkovic *1990 – Harold A. Scheraga *1991 – William W. Parson *1992 – Frank H. Westheimer *1993 – Jeremy R. Knowles *1994 – Judith P. Klinman *1995 – W. Wallace Cleland *1996 – William P. Jencks *1997 – James A. Spudich *1998 – David S. Eisenberg *1999 – Christopher T. Walsh *2000 – Perry A. Frey *2001 – Rowena G. Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly Award In Biological Chemistry
The Eli Lilly Award in Biological Chemistry was established in 1934. Consisting of a bronze medal and honorarium, its purpose is to stimulate fundamental research in biological chemistry by scientists not over thirty-eight years of age. The Award is administered by the Division of Biological Chemistry of the American Chemical Society. Recipients Past recipients of the Lilly Award: *1935 – Willard Myron Allen *1937 – *1938 – *1939 – George Wald *1940 – *1941 – David Rittenberg *1942 – Earl A. Evans, Jr. *1943 – Herbert E. Carter *1944 – Joseph S. Fruton *1945 – *1946 – John D. Ferry *1947 – *1948 – Dilworth Wayne Woolley *1949 – *1950 – *1951 – John M. Buchanan *1952 – *1953 – Nathan O. Kaplan *1954 – Harvey A. Itano *1955 – William F. Neuman *1956 – Robert A. Alberty *1957 – Harold A. Scheraga *1958 – Lester J. Reed *1959 – Paul Berg *1960 – James D. Watson *1961 – *1962 – Jerard Hurwitz *1963 – William ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Chemical Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c) organization, 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 60 Scientific journal, scholarly journals including the prestigious ''Journal of the American Chemical Society'', as well as the weekly tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circe Effect
The Circe effect is a phenomenon proposed by William Jencks seen in chemistry and biochemistry where in order to speed up a reaction, the ground state of the substrate is destabilized by an enzyme. Mechanism Highly favourable binding of a substrate at a non-reactive site will force the reactive site of the substrate to be more reactive by putting it in a very unfavourable position. This effect was observed in orotidine 5'-phosphate decarboxylase. This can occur by positioning a charged amino acid group next to the charged substrate thus destabilizing it, thus making the reaction occur faster. Furthermore, the substrate is put into an optimal position by the enzyme for the reaction to occur, thus decreasing the entropy greatly. Etymology This process was named after Circe in Homer's ''Odyssey The ''Odyssey'' (; grc, Ὀδύσσεια, Odýsseia, ) is one of two major Ancient Greek literature, ancient Greek Epic poetry, epic poems attributed to Homer. It is one of the oldes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbon
Carbon () is a chemical element with the symbol C and atomic number 6. It is nonmetallic and tetravalent In chemistry, the valence (US spelling) or valency (British spelling) of an element is the measure of its combining capacity with other atoms when it forms chemical compounds or molecules. Description The combining capacity, or affinity of an ...—its atom making four electrons available to form covalent bond, covalent chemical bonds. It belongs to group 14 of the periodic table. Carbon makes up only about 0.025 percent of Earth's crust. Three Isotopes of carbon, isotopes occur naturally, Carbon-12, C and Carbon-13, C being stable, while Carbon-14, C is a radionuclide, decaying with a half-life of about 5,730 years. Carbon is one of the Timeline of chemical element discoveries#Ancient discoveries, few elements known since antiquity. Carbon is the 15th Abundance of elements in Earth's crust, most abundant element in the Earth's crust, and the Abundance of the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
