Sf21 (officially called IPLB-Sf21-AE) is a continuous

cell line An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cell ...

developed from ovaries of the Fall Army worm, ''

Spodoptera frugiperda The fall armyworm (''Spodoptera frugiperda'') is a species in the order Lepidoptera and one of the species of the fall armyworm moths distinguished by their larval life stage. The term "armyworm" can refer to several species, often describing the ...

'', a

moth Moths are a paraphyletic group of insects that includes all members of the order Lepidoptera that are not butterflies, with moths making up the vast majority of the order. There are thought to be approximately 160,000 species of moth, many of w ...

species that is an agricultural pest on corn and other grass species. It was originally developed in the United States at the

Henry A. Wallace Beltsville Agricultural Research Center The Henry A. Wallace Beltsville Agricultural Research Center (BARC), also known as the National Agricultural Research Center, is a unit of the United States Department of Agriculture's Agricultural Research Service. It is located in unincorporat ...

Sf9 SF9 ( ko, 에스에프나인 ; shortened from Sensational Feeling 9) is a South Korean boy band formed by FNC Entertainment and the company's first dance boy group. Consisting of nine members, the group debuted on October 5, 2016 with the relea ...

is a substrain ( clone) of these cells that was isolated from Sf21 by researchers at

Texas A&M University Texas A&M University (Texas A&M, A&M, or TAMU) is a public, land-grant, research university in College Station, Texas. It was founded in 1876 and became the flagship institution of the Texas A&M University System in 1948. As of late 2021, T ...

. Both the clone and parent strains of the cells have been extensively used in research on

virus A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1 ...

es, especially

baculovirus ''Baculoviridae'' is a family of viruses. Arthropod Arthropods (, (gen. ποδός)) are invertebrate animals with an exoskeleton, a Segmentation (biology), segmented body, and paired jointed appendages. Arthropods form the phylum Arthropod ...

es in their use for producing recombinant proteins.

References

{{cite journal , author=Vaughn, J. L. , author2=Goodwin, R. H. , author3=Tompkins, G. J. , author4=McCawley, P. , name-list-style=amp , title= The establishment of two cell lines from the insect ''Spodoptera frugiperda'' (Lepidoptera: Noctuidae) , journal=In Vitro , year=1977 , volume=13 , pages=213–217 , doi= 10.1007/BF02615077 , pmid=68913 , issue=4

External links

Cellosaurus entry for Sf21
Insect cell lines Spodoptera