is a Japanese

physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...

and

metabolic disorder A metabolic disorder is a disorder that negatively alters the body's processing and distribution of macronutrients, such as proteins, fats, and carbohydrates. Metabolic disorders can happen when abnormal chemical reactions in the body alter the ...

researcher. He received the Uehara Award in 1990 while working as a professor at the University of Osaka. He also received the Takeda Medical Science Prize in 1995.

Biography

Seiichiro Tarui was born in Kōshien,

Nishinomiya 270px, Nishinomiya City Hall 270px, Aerial view of Nishinomiya city center 270px, Hirota Shrine is a city located in Hyōgo Prefecture, Japan. , the city had an estimated population of 484,368 in 218948 households and a population density of 48 ...

Hyōgo Prefecture is a prefecture of Japan located in the Kansai region of Honshu. Hyōgo Prefecture has a population of 5,469,762 () and has a geographic area of . Hyōgo Prefecture borders Kyoto Prefecture to the east, Osaka Prefecture to the southeast, an ...

. He qualified in medicine at the University of Osaka in 1953. From 1959 he was an assistant in the Second Department of Internal Medicine at this university, where he conducted clinical research on disorders of carbohydrate metabolism. He was appointed as Associate Professor of Internal Medicine in 1966, and in 1978 he was elevated to the chair of internal medicine. He retired with emeritus status in 1991. He then became Director of Otemae Hospital, Osaka.

Associated eponyms

Tarui's disease Phosphofructokinase deficiency is a rare muscular metabolic disorder, with an autosomal recessive inheritance pattern. It may affect humans as well as other mammals (especially dogs). It was named after the Japanese physician Seiichiro Tarui (b. ...

– An inborn error of

glycogen Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, fungi, and bacteria. The polysaccharide structure represents the main storage form of glucose in the body. Glycogen functions as one o ...

metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...

characterized by phosphofructokinase deficiency in the muscles, associated with abnormal deposition of glycogen in muscle tissues. Tarui disease typically manifests itself in childhood with exercise intolerance and anaemia. The fatal variant normally onsets within the first year of life, and all reported cases have died before the age of four. The adult variant normally sets in during late adulthood in the form of progressive limb muscle weakness without myoglobinuria or cramps.

References

1927 births Possibly living people Japanese healthcare managers Japanese endocrinologists {{Japan-bio-stub