Scott A. Waldman is an
MD and
biomedical scientist A biomedical scientist is a scientist trained in biology, particularly in the context of medical laboratory sciences or laboratory medicine. These scientists work to gain knowledge on the main principles of how the human body works and to find new w ...
at
Sidney Kimmel Medical College
Thomas Jefferson University is a private research university in Philadelphia, Pennsylvania. Established in its earliest form in 1824, the university officially combined with Philadelphia University in 2017. To signify its heritage, the unive ...
of
Thomas Jefferson University
Thomas Jefferson University is a private research university in Philadelphia, Pennsylvania. Established in its earliest form in 1824, the university officially combined with Philadelphia University in 2017. To signify its heritage, the univer ...
, where he is the Samuel M.V. Hamilton Professor of Medicine, and also tenured professor and
chair
A chair is a type of seat, typically designed for one person and consisting of one or more legs, a flat or slightly angled seat and a back-rest. They may be made of wood, metal, or synthetic materials, and may be padded or upholstered in vario ...
of the Department of Pharmacology & Experimental Therapeutics. He is author of a pharmacology textbook, and former
chief editor
An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies.
The highest-ranking editor of a publication may also be titled editor, managing ...
of
Clinical Pharmacology & Therapeutics
''Clinical Pharmacology & Therapeutics'' is a monthly peer-reviewed medical journal which covers research on the nature, action, efficacy, and evaluation of therapeutics. The editor-in-chief is Piet van der GraafCetara. The journal was establishe ...
. He is known for his work in
atrial natriuretic factor
Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. Natriuretic peptides (ANP, BNP, and CNP) are a family of hormone/pa ...
intracellular signaling
In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellula ...
through
guanylate cyclase
Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanos ...
(GC), and the relation of
Guanylyl cyclase C
Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the ''GUCY2C'' gene.
Guanylyl cyc ...
(GC-C) to the
pathogenesis
Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pat ...
of
colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel m ...
. Also for his hypotheses concerning the roles of intestinal
paracrine hormones (
uroguanylin
Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte an ...
,
guanylin
Guanylin is a 15 amino acid peptide that is secreted by goblet cells in the colon. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia. Upon receptor bi ...
) in
satiety
Satiety ( ) is a state or condition of fullness gratified beyond the point of satisfaction, the opposite of hunger. It is a state which induces meal termination.Hetherington, M.Sensory-specific satiety and its importance in meal termination ''Neuro ...
,
obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's we ...
and
cancer risk. Waldman also holds a concurrent position as adjunct professor at the
University of Delaware
The University of Delaware (colloquially UD or Delaware) is a public land-grant research university located in Newark, Delaware. UD is the largest university in Delaware. It offers three associate's programs, 148 bachelor's programs, 121 mas ...
, School of Health Sciences.
Education
Waldman was born in
Brooklyn
Brooklyn () is a borough of New York City, coextensive with Kings County, in the U.S. state of New York. Kings County is the most populous county in the State of New York, and the second-most densely populated county in the United States, be ...
,
New York
New York most commonly refers to:
* New York City, the most populous city in the United States, located in the state of New York
* New York (state), a state in the northeastern United States
New York may also refer to:
Film and television
* '' ...
on October 22, 1953. He completed a BS degree in biology from the
State University of New York at Albany
The State University of New York at Albany, commonly referred to as the University at Albany, UAlbany or SUNY Albany, is a public research university with campuses in Albany, Rensselaer, and Guilderland, New York. Founded in 1844, it is one ...
in 1975, followed by a Ph.D. degree in Human Anatomy from Thomas Jefferson University, Philadelphia (1980), where he worked at the Daniel Baugh Institute of Anatomy.
He completed postdoctoral fellowships in pharmacology first at University of Virginia (1981) and then at Stanford University (1983). He then attended medical school, and graduated as an MD from
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
, Palo Alto (1987). He then had his internship (1987–1988) and clinical residency (1988–1990) in the department of medicine,
Stanford University Hospital, Palo Alto.
Academic career
After his clinical training he became an assistant professor in the Division of Clinical Pharmacology in the department of medicine of Thomas Jefferson University in 1990. Since then he has remained at Jefferson Medical College, where he has stepped up the academic ladder to Samuel M.V. Hamilton Professor of Medicine (since 1998), and tenured professor and chair of the Department of Pharmacology and Experimental Therapeutics (since 2005).
At Jefferson, he has acted as director of the Jefferson Center for Individualized Medicine (2011–2015), Since 2010 he has also been associate dean of clinical and translational sciences at Jefferson Medical College (2010–2016), and vice president of clinical and translational research at Thomas Jefferson University (2010–2016). Since 2012 Waldman has held a concurrent position as an adjunct professor at the School of Health Sciences of the University of Delaware. He is also director of the Gastrointestinal Malignancies Program at the Sidney Kimmel Cancer Center of Thomas Jefferson University. From 2017 to 2020, Waldman was a visiting professor at the Xuzhou Cancer Hospital, Xuzhou, China.
From 1983 to 1990 Waldman was a staff pharmacologist at the Veterans Administration Medical Center, Palo Alto. From 1991 to 1997 he was the medical director of the Clinical Research Unit at
Thomas Jefferson University Hospital
Thomas Jefferson University Hospital is the flagship hospital of Jefferson Health, a multi-state non-profit health system based in Philadelphia. The hospital serves as the teaching hospital for Thomas Jefferson University.
History
Originally form ...
, where he now is an attending physician.
Institutional profiles with details of Waldman's career are visible on the internet.
Academic service
Waldman has lent academic service by his participation in committees of institutions such as NIH and FDA, in areas like clinical pharmacology training, translational research, and extramural activities.
Awards
* 2010 – Henry Elliott Distinguished Service Award, American Society for Clinical Pharmacology and Therapeutics
* 2011 – PhRMA Foundation Award in Excellence in Clinical Pharmacology
* 2012 – Rawls Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics
* 2015 – Reynold Spector Award in Clinical Pharmacology,
* 2017 – Elected Fellow,
National Academy of Inventors
The National Academy of Inventors (NAI) is a US non-profit organization dedicated to encouraging inventors in academia, following the model of the National Academies of the United States. It was founded at the University of South Florida in 2010. ...
* 2020 – Elected Fellow of the American Society for Pharmacology and Experimental Therapeutics
Works
Research
His early career was devoted to characterize the receptor-mediated responses to atrial natriuretic peptide (ANP) in vascular smooth muscle and other cell types, especially its stimulation of guanylyl cyclase to cause the intracellular accumulation of cGMP in the context of vasodilatory phenomena. His subsequent studies on the ANP-like stimulation of guanylyl cyclase by enterotoxins eventually led to new research venues into the study of guanylyl cyclase C and its role in the pathogenesis of colorectal cancer.
Recently, Waldman has extensively explored concepts surrounding the role of membrane-bound
GUCY2C receptors lining the gastrointestinal tract in relation to the homeostatic regulation of the
crypt-surface axis by paracrine hormones uroguanylin and guanylin. His recent research includes the experimental targeting of such receptors in various ways for the treatment of inflammatory bowel disease and colorectal neoplasias, including (under his leadership) a phase-I clinical trial to test a recombinant vaccine against colorectal cancer aimed to immunize against GUCY2C receptors.
Publications
He was the former
chief editor
An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies.
The highest-ranking editor of a publication may also be titled editor, managing ...
of
Clinical Pharmacology & Therapeutics
''Clinical Pharmacology & Therapeutics'' is a monthly peer-reviewed medical journal which covers research on the nature, action, efficacy, and evaluation of therapeutics. The editor-in-chief is Piet van der GraafCetara. The journal was establishe ...
Peer-reviewed journal articles
Waldman has published over 300 research articles in peer-reviewed journals.
His most cited articles are:
* SA Waldman, RM Rapoport, F Murad (1984) Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues./ Journal of Biological Chemistry 259 (23), 14332–14334 According to Google Scholar, this article has been cited 755 times.
* R J Winquist, E P Faison, S A Waldman, K Schwartz, F Murad, and R M Rapoport (1984) Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. PNAS December 1, 1984 81 (23) 7661–7664; According to Google Scholar, this article has been cited 598 times.
* Jozef Bartunek, Atta Behfar, Dariouch Dolatabadi, Marc Vanderheyden, Miodrag Ostojic, Jo Dens, Badih El Nakadi, Marko Banovic, Branko Beleslin, Mathias Vrolix, Victor Legrand, Christian Vrints, Jean Louis Vanoverschelde, Ruben Crespo-Diaz, Christian Homsy, Michal Tendera, Scott Waldman, William Wijns, Andre Terzic. ( June 2013) Cardiopoietic Stem Cell Therapy in Heart Failure; The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) Multicenter Randomized Trial With Lineage-Specified Biologics. ''Journal of the American College of Cardiology'' Volume 61, Issue 23, DOI: 10.1016/j.jacc.2013.02.071 According to Google Scholar, this article has been cited 400 times.
Reviews
Waldman has authored over 50 research review articles.
His most cited reviews are:
* Lucas, K. A., Pitari, G. M., Kazerounian, S., Ruiz-Stewart, I., Park, J., Schulz, S., Chepenik KP & Waldman, S. A. (2000). Guanylyl cyclases and signaling by cyclic GMP. Pharmacological reviews, 52(3), 375–414.Guanylyl cyclases and cyclic GMP, According to Google Scholar, this review has been cited 1439 times.
* SA Waldman, Cyclic GMP synthesis and function,
Pharmacological Reviews'' 39, 163-196 (1987) According to Google Scholar, this review has been cited 1047 times.
''
Books
Together with Andre Terzic, in 2009 Waldman was co-editor of the multi-author textbook ''Pharmacology and Therapeutics'': ''Principles to Practice'', , (Saunders-Elsevier)
References
External links
Scott A. Walman's academic website
{{DEFAULTSORT:Waldman, Scott
Living people
1953 births
Stanford University School of Medicine alumni
University at Albany, SUNY alumni
Jefferson Medical College faculty
People from Brooklyn
Fellows of the American Society for Pharmacology and Experimental Therapeutics