Sarah C. Darby is

Professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who pr ...

Medical Statistics Medical statistics deals with applications of statistics to medicine and the health sciences, including epidemiology, public health, forensic medicine, and clinical research. Medical statistics has been a recognized branch of statistics in the U ...

at the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

. Her research has focused the beneficial effects of

smoking Smoking is a practice in which a substance is burned and the resulting smoke is typically breathed in to be tasted and absorbed into the bloodstream. Most commonly, the substance used is the dried leaves of the tobacco plant, which have bee ...

cessation, the risk of

lung cancer Lung cancer, also known as lung carcinoma (since about 98–99% of all lung cancers are carcinomas), is a malignant lung tumor characterized by uncontrolled cell growth in tissue (biology), tissues of the lung. Lung carcinomas derive from tran ...

from residential

radon Radon is a chemical element with the symbol Rn and atomic number 86. It is a radioactive, colourless, odourless, tasteless noble gas. It occurs naturally in minute quantities as an intermediate step in the normal radioactive decay chains through ...

, and treatments for early

breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...

. She is also a Principal Scientist with the

Cancer Research UK Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

in the

Clinical Trial Service Unit The Clinical Trial Service Unit (CTSU) is a medical research institute within the Nuffield Department of Population Health at Oxford University. It primarily conducts large scale clinical trials (phase III – Final Testing) and epidemiological ...

(CTSU) and

Epidemiological Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidenc ...

Studies Unit at the

Nuffield Department of Clinical Medicine Nuffield may refer to: *William Morris, 1st Viscount Nuffield, founder of Oxford-based Morris Motors and philanthropist *Nuffield, Oxfordshire, a village in Oxfordshire, England and home of William Richard Morris from which he chose his title, Visc ...

, at the

Radcliffe Infirmary The Radcliffe Infirmary was a hospital in central north Oxford, England, located at the southern end of Woodstock Road on the western side, backing onto Walton Street. History The initial proposals to build a hospital in Oxford were put forw ...

, Oxford.

Education

Darby studied

Mathematics Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics ...

Imperial College London Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...

(BSc) and

Mathematical Statistics Mathematical statistics is the application of probability theory, a branch of mathematics, to statistics, as opposed to techniques for collecting statistical data. Specific mathematical techniques which are used for this include mathematical an ...

at the

University of Birmingham , mottoeng = Through efforts to heights , established = 1825 – Birmingham School of Medicine and Surgery1836 – Birmingham Royal School of Medicine and Surgery1843 – Queen's College1875 – Mason Science College1898 – Mason Univers ...

(MSc). She completed her PhD at the

London School of Hygiene and Tropical Medicine The London School of Hygiene and Tropical Medicine (LSHTM) is a public research university in Bloomsbury, central London, and a member institution of the University of London that specialises in public health and tropical medicine. The inst ...

in 1977 where her research investigated

Bayesian Thomas Bayes (/beɪz/; c. 1701 – 1761) was an English statistician, philosopher, and Presbyterian minister. Bayesian () refers either to a range of concepts and approaches that relate to statistical methods based on Bayes' theorem, or a followe ...

approaches to analysing

bioassay A bioassay is an analytical method to determine the concentration or potency of a substance by its effect on living animals or plants (''in vivo''), or on living cells or tissues(''in vitro''). A bioassay can be either quantal or quantitative, dir ...

Career and research

After her PhD, she worked at

St Thomas's Hospital Medical School St Thomas's Hospital Medical School in London was one of the oldest and most prestigious medical schools in the UK. The school was absorbed to form part of King's College London. History It was part of one of the oldest hospitals in London, ...

, the

National Radiological Protection Board The National Radiological Protection Board (NRPB) was a public authority_in_the_United_Kingdom.html" ;"title="110. - 6910./ref> is a type of Nonprofit organization">nonprofit corporation chartered by a state governments of the United States, state g ...

, and the

Radiation Effects Research Foundation The Radiation Effects Research Foundation (RERF) is a joint U.S.-Japan research organization responsible for studying the medical effects of radiation and associated diseases in humans for the welfare of the survivors and all humankind.Introduction ...

Hiroshima is the capital of Hiroshima Prefecture in Japan. , the city had an estimated population of 1,199,391. The gross domestic product (GDP) in Greater Hiroshima, Hiroshima Urban Employment Area, was US$61.3 billion as of 2010. Kazumi Matsui h ...

, before moving to the University of Oxford in 1984. Her major funder since then has been

. Darby and her team have demonstrated that there is a linear relationship between the dose of radiation delivered incidentally to the heart during

radiotherapy Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radia ...

and the subsequent risk of

ischaemic Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems wi ...

heart disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, hea ...

, and that the absolute size of the radiation-related risk is bigger for women already at increased risk of heart disease. She and her team have also estimated the absolute size of the benefit of radiotherapy to breast cancer patients and their work is enabling comparison of the likely absolute benefit of radiotherapy with its likely absolute risk for individual patients. Therefore, it is now becoming possible to assess which patients can receive standard radiotherapy, which should be considered for advanced techniques, and which should avoid radiotherapy altogether. Other topics that Darby has worked on include estimating the risk of

from residential

, the risk of invasive breast cancer after a diagnosis of ductal

carcinoma Carcinoma is a malignancy that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal ...

in situ ''In situ'' (; often not italicized in English) is a Latin phrase that translates literally to "on site" or "in position." It can mean "locally", "on site", "on the premises", or "in place" to describe where an event takes place and is used in ...

'', and the risk of cancer after computerised tomography (CT) scans in young people.

Awards and honours

Darby was awarded the

Guy Medal The Guy Medals are awarded by the Royal Statistical Society in three categories; Gold, Silver and Bronze. The Silver and Bronze medals are awarded annually. The Gold Medal was awarded every three years between 1987 and 2011, but is awarded biennia ...

in Bronze in 1988 by the

Royal Statistical Society The Royal Statistical Society (RSS) is an established statistical society. It has three main roles: a British learned society for statistics, a professional body for statisticians and a charity which promotes statistics for the public good. ...

.Royal Statistical Society Guy Medal in Bronze
MacTutor History of Mathematics Archive She was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

(FRS) in 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

References

{{DEFAULTSORT:Darby, Sarah British women epidemiologists Living people Fellows of Green Templeton College, Oxford Women statisticians Year of birth missing (living people) Fellows of the Royal Society British statisticians Female Fellows of the Royal Society