Sangivamycin is a

natural product A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical syn ...

originally isolated from ''

Streptomyces rimosus ''Streptomyces rimosus'' is a bacterium species in the genus '' Streptomyces''. Uses The antibiotics oxytetracycline and tetracycline are produced in cultures of ''S. rimosus''. Paromomycin has also been isolated from cultures of ''S. rimosu ...

'', which is a nucleoside analogue. It acts as an inhibitor of

protein kinase C In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ...

. It has

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...

, antiviral and anti-cancer properties and has been investigated for various medical applications, though never approved for clinical use itself. However, a number of related derivatives continue to be researched. Oyagen, a biotechnology company, has been developing sangivamycin or OYA1, which showed efficacy against Ebola infections, as a broad spectrum antiviral for COVID-19.

Tonix Pharmaceuticals Tonix Pharmaceuticals (Tonix Pharmaceuticals Holding Corp.) is a pharmaceutical company based in Chatham, New jersey that focuses on drug repurposing, repurposed drugs for central nervous system conditions and as of 2020 was also pursuing a vaccin ...

licensed OYA1 from Oyagen in April 2021 to develop it for the treatment of COVID-19 and it is now called TNX-3500.

References

{{antiinfective-drug-stub Antiviral drugs

See also

References