Sir Samuel Wilks, 1st Baronet, (2 June 1824 – 8 November 1911) was a British physician and

biographer Biographers are authors who write an account of another person's life, while autobiographers are authors who write their own biography. Biographers Countries of working life: Ab=Arabia, AG=Ancient Greece, Al=Australia, Am=Armenian, AR=Ancient Rome ...

Early life

Samuel Wilks was born on 2 June 1824 in Camberwell, London, the second son of Joseph Barber Wilks, a cashier at the East India House. After attending

Aldenham School Aldenham School is a co-educational independent school for pupils aged eleven to eighteen, located between Elstree and the village of Aldenham in Hertfordshire, England. There is also a preparatory school for pupils from the ages of five to ele ...

and

University College School ("Slowly but surely") , established = , closed = , type = Public schoolIndependent day school , religion = , president = , head_label = Headmaster , head = Mark Beard , r_head_label = , r_he ...

he was apprenticed to Richard Prior, a doctor in Newington.

Career

In 1842 he entered

Guy's Hospital Guy's Hospital is an NHS hospital in the borough of Southwark in central London. It is part of Guy's and St Thomas' NHS Foundation Trust and one of the institutions that comprise the King's Health Partners, an academic health science centre. ...

to study medicine. After graduating MB in 1848 he was hired as a physician to the Surrey Infirmary (1853). In 1856 he returned to Guy's Hospital, first as assistant physician and

curator A curator (from la, cura, meaning "to take care") is a manager or overseer. When working with cultural organizations, a curator is typically a "collections curator" or an "exhibitions curator", and has multifaceted tasks dependent on the parti ...

of its museum (a post he held for nine years), then as physician and lecturer on medicine (1857). From 1866 to 1870 he was examiner in the practice of medicine at the

University of London The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degr ...

and from 1868 to 1875 examiner in medicine at the

Royal College of Surgeons The Royal College of Surgeons is an ancient college (a form of corporation) established in England to regulate the activity of surgeons. Derivative organisations survive in many present and former members of the Commonwealth. These organisations ...

Achievements

Among his major discoveries, Wilks recognised

ulcerative colitis Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood (hematochezia). Weight loss, fever, and ...

in 1859, differentiating it from bacterial

dysentery Dysentery (UK pronunciation: , US: ), historically known as the bloody flux, is a type of gastroenteritis that results in bloody diarrhea. Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. Complications ...

. His work was confirmed later (1931) by Sir Arthur Hurst. Wilks's autopsy of a 42-year-old woman who died after several months of

diarrhoea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wi ...

and

fever Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...

demonstrated a transmural ulcerative

inflammation Inflammation (from la, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molec ...

of the colon and terminal

ileum The ileum () is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine m ...

. Wilks also firstly described trichorrhexis nodosa (the formation of nodes along the hair shaft), in 1852. The term was proposed in 1876 by

Moritz Kaposi Moritz Kaposi ( hu, Kaposi Mór, ; 23 October 1837 in Kaposvár, Hungary – 6 March 1902 in Vienna, Austria-Hungary) was a Hungarian physician and dermatologist who discovered the skin tumor that received his name (Kaposi's sarcoma). Biography ...

(1837–1902), a Hungarian

dermatologist Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medica ...

. In 1957, he provided the first autopsy description of a condition of the upper airways, later known as tracheobronchopathia osteochondroplastica. Subsequently, in 1868, he published the characteristic mental symptoms on alcoholic paraplegia (later to be named Korsakoff's syndrome). Wilks described the first case of myasthenia gravis, in 1877 (it was named "bulbar paralysis" in ''Guy's Hospital Reports'' 22:7). He was a collaborator and biographer of the "Three Great", contemporary physicians who worked at Guy's Hospital, Dr.

Thomas Addison Thomas J Addison (April 179329 June 1860) was an English physician, chef, and scientist. He is traditionally regarded as one of the "great men" of Guy's Hospital in London. Among other pathologies, he discovered Addison's disease (a degenerati ...

, the discoverer of

Addison's disease Addison's disease, also known as primary adrenal insufficiency, is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adre ...

, Dr. Richard Bright, discoverer of

Bright's disease Bright's disease is a historical classification of kidney diseases that are described in modern medicine as acute or chronic nephritis. It was characterized by swelling and the presence of albumin in the urine, and was frequently accompanied ...

and Dr.

Thomas Hodgkin Thomas Hodgkin RMS (17 August 1798 – 5 April 1866) was a British physician, considered one of the most prominent pathologists of his time and a pioneer in preventive medicine. He is now best known for the first account of Hodgkin's disease, ...

, discoverer of

Hodgkin's lymphoma Hodgkin lymphoma (HL) is a type of lymphoma, in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells (RS cells) are present in the patient's lymph nodes. The condition w ...

. After the death of Addison in 1860, he carried out the job of examining specimens from all over the country in order to confirm the diagnosis of Addison's disease and thus was able to amass a large case archive. He also rediscovered and confirmed the existence of Hodgkin's lymphoma, at the same time recognizing Hodgkin's priority and proposing the

eponym An eponym is a person, a place, or a thing after whom or which someone or something is, or is believed to be, named. The adjectives which are derived from the word eponym include ''eponymous'' and ''eponymic''. Usage of the word The term ''epon ...

Honours and awards

Among his many services and honors, Wilks was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemat ...

in June 1870; was president of the Pathological Society (1881–1882); president of the Neurological Society (1887); member of the Senate of the University of London (1887–1900); member of the General Medicine Council (1887–1896) and president of the

Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...

(1896–1899). He was named Physician Extraordinary to

Queen Victoria Victoria (Alexandrina Victoria; 24 May 1819 – 22 January 1901) was Queen of the United Kingdom of Great Britain and Ireland from 20 June 1837 until her death in 1901. Her reign of 63 years and 216 days was longer than that of any previo ...

in 1897. The following year he was created a baronet, of Grosvenor Street in the Parish of Saint George Hanover Square in the County of London.

Later life

In later life he suffered a stroke and was terminally paraplegic. He died aged 87 at his home in Hampstead on 8 November 1911. After his death the baronetcy became extinct. He had married Mrs. Elizabeth Anne Prior, widow of previous employer Richard Prior; they had no children.

Publications

* ''Lectures on Pathological Anatomy'', 1869 * ''Lectures on the Specific Fevers and on Diseases of the Chest'', 1874 * ''Lectures on Diseases of the Nervous System'', 1878 * ''Lectures on Pathology Delivered at the London Hospital''. J & A Churchill, London, 1891. * ''A Biographical History of Guy's Hospital'', 1892 (with G. T. Bettany)
''The Relation of Man to the Animal World''
(1907)

References

* Kauntze R.: Samuel Wilks. ''Guy's Hosp Rep.'' 1970; 119(4):353-5. *

External links

The Wilks Report on Addison's Disease (1862) complete
{{DEFAULTSORT:Wilks, Samuel 1824 births 1911 deaths People from Camberwell 19th-century English medical doctors Baronets in the Baronetage of the United Kingdom Fellows of the Royal College of Physicians Fellows of the Royal Society Physicians of Guy's Hospital