Sorting nexin-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the SNX1
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
. The protein encoded by this gene is a
sorting nexin
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein intera ...
.
SNX1 is a component of the
retromer complex.
Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (
PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular
trafficking. This
endosomal protein regulates the cell-surface expression of
epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
The epidermal growth factor rec ...
. This protein also has a role in sorting
protease-activated receptor-1 from early endosomes to
lysosome
A lysosome () is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane ...
s. This protein may form oligomeric complexes with other family members.
References
Further reading
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External links
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