SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide
antagonist at the
melanin concentrating hormone
Melanin-concentrating hormone (MCH), also known as pro-melanin stimulating hormone (PMCH), is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation ...
receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
MCH1. In initial animal studies it had promising
anxiolytic
An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
,
antidepressant and
anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic.
The term is (from the Greek ''ἀν-'' (an-) = "without" a ...
effects,
but subsequent trial results were disappointing,
and the main significance of SNAP-7941 is as the
lead compound
A lead compound (, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacology, pharmacological or biological activity likely to be therapeutical ...
from which more potent and selective antagonists such as
SNAP-94847 were developed,
although it continues to be used for research into the function of the MCH
1 receptor.
References
Experimental antidepressants
Anxiolytics
Ethers
Fluoroarenes
Anilides
Pyrimidones
Methyl esters
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