STE20-like serine/threonine-protein kinase is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

that in humans is encoded by the ''SLK''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

Interactions

SLK (gene) has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

PDZK1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the ''PDZK1'' gene. Interactions PDZK1 has been shown to interact with: * AKAP10, * CLCN3, * Cystic fibrosis transmembrane conductance regulator * FARP ...

. SLK is a mammalian gene located on

chromosome 10 Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 133 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the tot ...

. it has also been cloned in rats. There is a whole family of STE20 like protein kinases, which has been divided into three categories. the most important p21-activated kinase (PAK), germinal center kinases (GCK) and Pleckstrin homology domain containing PAK (PHPAK). SLK gene plays an important role in development, termination and differentiation of cells and tissues. the main enzyme SLK gene produces is called Ste20-like kinases which was formerly known as Ste20-like serine/threonine protein kinase. the balanced expression of SLK gene is very essential for the correct development of body parts in all mammals. this enzyme is also involved in cell movement and cell cycle. The expression of SLK gene in germ line cell is regulated by phosphorylation of PLK1, which is another gene involved in mitosis. Ste20- like kinases manages the correct orientation of micro-tubules during inter-phase level of cell cycles. Underproduction of Ste20-like serine/threonine-protein kinases can result in micro-tubule fibers to detach from chromosomes. It also functions in activation/deactivation of apoptosis in cells, as well as organization and adhesion of cell to shape an appropriate organ. Cybulsky, Takano. “The Ste20-Like Kinase SLK Promotes P53 Transactivation and Apoptosis.” American Journal of Physiology. Renal Physiology 297.4 (2009): 971–980. Web

Interactions

References

Further reading