Septin-9 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''SEPT9''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Interactions
SEPT9 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
SEPT2
Septin 2, also known as SEPT2, is a protein which in humans is encoded by the ''SEPT2'' gene.
Function
SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. ...
and
SEPT7
Septin-7 is a protein that in humans is encoded by the ''SEPT7'' gene.
Function
This gene encodes a protein that is highly similar to the CDC10 protein of ''Saccharomyces cerevisiae''. The protein also shares similarity with Diff 6 of ''Drosop ...
.
[
]
Function
Along with AHNAK, eIF4E
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the ''EIF4E'' gene.
Structure and function
Most eukaryotic cellular mRNAs are blocked at their 5'-ends with the 7-methyl-guanosine f ...
and S100A11
S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the ''S100A11'' gene.
Function
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A ...
, SEPT9 has been shown to be essential for pseudopod protrusion, tumor cell migration and invasion.
Clinical significance
The v2 region of the SEPT9 promoter has been shown to be methylated
In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom. These ...
in colorectal cancer tissue compared with normal colonic mucosa.[, which cites
*
* ] It is similar in specificity and sensitivity to the stool guaiac test or fecal immune tests, and those tests should be used in preference.
See also
* Hereditary neuralgic amyotrophy
References
Further reading
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