Septin 2, also known as SEPT2, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
which in humans is encoded by the ''SEPT2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
SEPT2 can hetero-oligomerize with
SEPT6
Septin-6 is a protein that in humans is encoded by the ''SEPT6'' gene.
Function
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes four transcript variants encoding thr ...
and
SEPT7
Septin-7 is a protein that in humans is encoded by the ''SEPT7'' gene.
Function
This gene encodes a protein that is highly similar to the CDC10 protein of ''Saccharomyces cerevisiae''. The protein also shares similarity with Diff 6 of ''Drosoph ...
to form filaments.
SEPT2 interacted with SEPT6 through its
C-terminal
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH). When the protein is ...
coiled-coil
A coiled coil is a structural motif in proteins in which 2–7
alpha helix, alpha-helices are coiled together like the strands of a rope. (Protein dimer, Dimers and Protein trimer, trimers are the most common types.) Many coiled coil-type protei ...
domain.
of SEPT2, SEPT6, and SEPT7 in causes
actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over ...
stress fibers to disintegrate and cells to lose
polarity
Polarity may refer to:
Science
*Electrical polarity, direction of electrical current
*Polarity (mutual inductance), the relationship between components such as transformer windings
* Polarity (projective geometry), in mathematics, a duality of ord ...
. Septins,
SOCS7
Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the ''SOCS7'' gene.
Model organisms
Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called ''Socs7tm1a(EUCOMM)Wtsi'' wa ...
, and
NCK1
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the ''NCK1'' gene.
Gene
The Nck (non-catalytic region of tyrosine kinase adaptor protein 1) belongs to the adaptor family of proteins. The nck gene was initially isolated from ...
are part of a signaling pathway that couples regulation of the DNA damage response to the cytoskeleton.
Interactions
SEPT2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
SEPT6
Septin-6 is a protein that in humans is encoded by the ''SEPT6'' gene.
Function
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes four transcript variants encoding thr ...
SEPT7
Septin-7 is a protein that in humans is encoded by the ''SEPT7'' gene.
Function
This gene encodes a protein that is highly similar to the CDC10 protein of ''Saccharomyces cerevisiae''. The protein also shares similarity with Diff 6 of ''Drosoph ...
,SEPT9
Septin-9 is a protein that in humans is encoded by the ''SEPT9'' gene.
Interactions
SEPT9 has been shown to interact with SEPT2 and SEPT7.
Function
Along with AHNAK, eIF4E and S100A11, SEPT9 has been shown to be essential for pseudopod pr ...
.
References
Further reading
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