Route 51 is a highway in southeastern

Missouri Missouri is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it is bordered by eight states (tied for the most with Tennessee ...

. Its northern terminus is the

Illinois Illinois ( ) is a U.S. state, state in the Midwestern United States, Midwestern United States. Its largest metropolitan areas include the Chicago metropolitan area, and the Metro East section, of Greater St. Louis. Other smaller metropolita ...

state line near

Chester, Illinois Chester is a city in and the county seat of Randolph County, Illinois, United States, on a bluff above the Mississippi River. The population was 6,814 at the 2020 census. It lies south of St. Louis, Missouri. History Founding Samuel Smith is ...

; its southern terminus is at the

Arkansas Arkansas ( ) is a landlocked state in the South Central United States. It is bordered by Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, and Texas and Oklahoma to the west. Its name is from the Osage ...

state line northwest of

Piggott, Arkansas Piggott is a city in Clay County, Arkansas, United States. It is one of the two county seats of Clay County, along with Corning. It is the northern terminus of the Arkansas segment of the Crowley's Ridge Parkway, a National Scenic Byway. As of the ...

. It continues into Illinois as

Illinois Route 150 Illinois Route 150 (IL 150) is a east–west state road in southern Illinois. It runs from the Chester Bridge, a truss bridge over the Mississippi River to Route 51 in the state of Missouri, to IL 154 in rural Perry County well west of Pinckn ...

and it continues into Arkansas as Highway 139. Route 51 is one of the original 1922 state highways and ran from the

Mississippi River The Mississippi River is the second-longest river and chief river of the second-largest drainage system in North America, second only to the Hudson Bay drainage system. From its traditional source of Lake Itasca in northern Minnesota, it f ...

Advance Advance commonly refers to: *Advance, an offensive push in sports, games, thoughts, military combat, or sexual or romantic pursuits *Advance payment for goods or services *Advance against royalties, a payment to be offset against future royalty pa ...

. Route 51A, a branch route, formerly connected Route 51 with Puxico when Route 51 ended at Advance (at Route 25). Route 51A would become part of the main highway when it was re-routed and extended.

Route description

History

Major intersections

Former suffixed route

References

051 Transportation in Butler County, Missouri Transportation in Stoddard County, Missouri Transportation in Bollinger County, Missouri Transportation in Perry County, Missouri {{Missouri-road-stub