Rocaglamide is a natural product which belongs to a class of molecules called
flavagline
Flavaglines are a family of natural products that are found in plants of the genus ''Aglaia'' (Meliaceae). These compounds are characterized by a cyclopenta 'b''enzofuran skeleton. In 1982 King and colleagues discovered the first member of this ...
s. This compound was isolated in 1982 by King, Ming-Lu (金明儒) and colleagues based on its antileukemic activity. The name of Rocaglamide is named from two parts: Roc- and aglamide. Roc- means Republic of China(中華民國), the place in which this product isolated; aglamide indicates this product is isolated from Large-leaved Aglaia (Scientific name:
Aglaia rimosa
''Aglaia rimosa'' is an evergreen small tree It is found in Indonesia, Papua New Guinea, the Philippines, and Taiwan (Hengchun, Hengchun Peninsula and Orchid Island ). ''Aglaia rimosa'' "grows primarily in the wet tropical biome".The official nam ...
Rocaglamide was first synthesized by
Barry Trost
Barry M. Trost (born June 13, 1941, in Philadelphia) is an American chemist who is the Job and Gertrud Tamaki Professor Emeritus in the School of Humanities and Sciences at Stanford University. The Tsuji-Trost reaction and the Trost ligand are ...
in 1990.
Although other syntheses have been described since, Trost’s remains the only one to afford rocaglamide in an
enantio-specific manner.
See also
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FL3 (flavagline)
FL3 is a synthetic flavagline that displays potent anticarcinogen, anticancer and cardioprotectant activities. This compound induces the death of cancer cells by an original mechanism that involves the apoptosis-inducing factor and caspase 12, sug ...
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Eukaryotic translation
Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes. It consists of four phases: gene translation, elongation, termination, and recapping.
Initiation
Translation initiation is the pr ...
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eIF4A
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that f ...
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Silvestrol
Silvestrol is a natural product from the flavagline family, with a cyclopenta enzofuran core structure and an unusual dioxane ether side chain, which is found in the bark of trees from the genus ''Aglaia'', especially '' Aglaia silvestris'' and ' ...
References
Carboxamides
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