Robert Roskoski Jr. is the Scientific Director and President of the
Blue Ridge Institute for Medical Research
The Blue Ridge Institute for Medical Research (BRIMR) is an independent, non-profit, scientific research institute located in Horse Shoe, North Carolina. The Institute was founded by Robert Roskoski Jr., who serves as President and Scientific Dire ...
.
Education
Roskoski studied chemistry at
Bowling Green State University, receiving a B.S. degree in 1961. He received an M.D. in 1964 and a Ph.D. in 1968 from the
University of Chicago. His doctoral adviser was
Donald F. Steiner
Donald Frederick Steiner (July 15, 1930 – November 11, 2014) was an American biochemist and a professor at the University of Chicago.
Birth and education
Donald F. Steiner was born in 1930 in Lima, Ohio. He completed his B.S. in Chemistry ...
, the discoverer of
proinsulin. Roskoski was in the medical corps of the
United States Air Force. Later, He became a Senior Investigator at the U.S. Air Force School of Aerospace Medicine at
Brooks Air Force Base in San Antonio. He subsequently performed postdoctoral studies at the
Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...
under the tutelage of
Fritz Lipmann from 1969 to 1972.
Research and career
Robert Roskoski did research on the classification of small molecule
protein kinase inhibitors that are used in the treatment of several cancers and he also developed the Gold Standard procedure for the measurement of Protein Kinase Enzyme Activity. His research interests include Protein kinase structure and function,
Cancer chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothera ...
, and
Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellula ...
.
He studied protein kinase structure and function and signal transduction. He also founded the Blue Ridge Institute for Medical Research in Horse Shoe, North Carolina in 2006. Research at the institute focuses on FDA-approved protein kinase inhibitors and monitoring extramural
NIH grant support.
Awards and honors
Robert Roskoski received the NIH Postdoctoral membership and NIH Special postdoctoral membership. From 1991 to 2006, he was the Fred G. Brazda Professor of Biochemistry at LSU Health Sciences Center in New Orleans.
American Chemical Society honors
Publications
* Roskoski R Jr. (1983) Assays of protein kinase. Methods in Enzymology 99, 3–6.
* Roskoski R Jr. (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys. Res. Commun. 331, 1–14.
* Roskoski R Jr. (2007) Vascular endothelial growth factor (VEGF) signalling in tumor progression. Crit. Rev. Oncol. Hematol. 62, 179–213.
* Roskoski R Jr. (2012) ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacol. Res. 66, 105–143.
* Roskoski R Jr. (2014) The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol. Res. 79, 34–74.
* Roskoski R Jr. A historical overview of protein kinases and their targeted small molecule inhibitors. Pharmacol Res 2015;100:1–23.
* Roskoski R Jr. (2016) Classification of small molecule inhibitors based upon the structures of their drug enzyme complexes. Pharmacol. Res. 103, 26–48.
References
External links
*
{{DEFAULTSORT:Roskoski, Robert
Living people
American medical researchers
Year of birth missing (living people)