|
Robert Roskoski
Robert Roskoski Jr. is the Scientific Director and President of the Blue Ridge Institute for Medical Research. Education Roskoski studied chemistry at Bowling Green State University, receiving a B.S. degree in 1961. He received an M.D. in 1964 and a Ph.D. in 1968 from the University of Chicago. His doctoral adviser was Donald F. Steiner, the discoverer of proinsulin. Roskoski was in the medical corps of the United States Air Force. Later, He became a Senior Investigator at the U.S. Air Force School of Aerospace Medicine at Brooks Air Force Base in San Antonio. He subsequently performed postdoctoral studies at the Rockefeller University under the tutelage of Fritz Lipmann from 1969 to 1972. Research and career Robert Roskoski did research on the classification of small molecule protein kinase inhibitors that are used in the treatment of several cancers and he also developed the Gold Standard procedure for the measurement of Protein Kinase Enzyme Activity. His research in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blue Ridge Institute For Medical Research
The Blue Ridge Institute for Medical Research (BRIMR) is an independent, non-profit, scientific research institute located in Horse Shoe, North Carolina. The Institute was founded by Robert Roskoski Jr., who serves as President and Scientific Director. Mission The general goals of the Institute are to explore the interrelationships of fundamental biological science, clinical science, and clinical care. Research Research at BRIMR focuses on the structure and regulation of protein kinases, their downstream signaling pathways, and therapeutic drugs that inhibit these enzymes. Protein kinases regulate the activity of their substrate targets by adding phosphate groups in a reaction known as protein phosphorylation. The United States Food and Drug Administration has approved the use of about 50 protein kinase inhibitors for the treatment of several cancers including those of breast, kidney, and lung and inflammatory diseases such as rheumatoid arthritis and ulcerative colitis. An av ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bowling Green State University
Bowling Green State University (BGSU) is a public research university in Bowling Green, Ohio. The main academic and residential campus is south of Toledo, Ohio. The university has nationally recognized programs and research facilities in the natural and social sciences, education, arts, business, health and wellness, humanities and applied technologies. The institution was granted a charter in 1910 as a normal school, specializing in teacher training and education, as part of the Lowry Normal School Bill that authorized two new normal schools in the state of Ohio. Over the university's history, it has developed from a small rural normal school into a comprehensive public research university. It is a part of University System of Ohio and classified among "R2: Doctoral Universities – High research activity". In 2019, Bowling Green offered over 200 undergraduate programs, as well as master's and doctoral degrees through eight academic colleges. BGSU had an on-campus resident ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Chicago
The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the best universities in the world and it is among the most selective in the United States. The university is composed of an undergraduate college and five graduate research divisions, which contain all of the university's graduate programs and interdisciplinary committees. Chicago has eight professional schools: the Law School, the Booth School of Business, the Pritzker School of Medicine, the Crown Family School of Social Work, Policy, and Practice, the Harris School of Public Policy, the Divinity School, the Graham School of Continuing Liberal and Professional Studies, and the Pritzker School of Molecular Engineering. The university has additional campuses and centers in London, Paris, Beijing, Delhi, and Hong Kong, as well as in downtown ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Donald F
Donald is a masculine given name derived from the Gaelic name ''Dòmhnall''.. This comes from the Proto-Celtic *''Dumno-ualos'' ("world-ruler" or "world-wielder"). The final -''d'' in ''Donald'' is partly derived from a misinterpretation of the Gaelic pronunciation by English speakers, and partly associated with the spelling of similar-sounding Germanic names, such as ''Ronald''. A short form of ''Donald'' is ''Don''. Pet forms of ''Donald'' include ''Donnie'' and ''Donny''. The feminine given name ''Donella'' is derived from ''Donald''. ''Donald'' has cognates in other Celtic languages: Modern Irish ''Dónal'' (anglicised as ''Donal'' and ''Donall'');. Scottish Gaelic ''Dòmhnall'', ''Domhnull'' and ''Dòmhnull''; Welsh '' Dyfnwal'' and Cumbric ''Dumnagual''. Although the feminine given name ''Donna'' is sometimes used as a feminine form of ''Donald'', the names are not etymologically related. Variations Kings and noblemen Domnall or Domhnall is the name of many ancie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proinsulin
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the ''INS'' gene. The islets of Langerhans only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood. There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induced by insulin. Proinsulin is the final single chain protein structure secreted by cells before cleavage into mature insulin. Proinsulin was discovered by Professor Donald F. Steiner of the Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Air Force
The United States Air Force (USAF) is the air service branch of the United States Armed Forces, and is one of the eight uniformed services of the United States. Originally created on 1 August 1907, as a part of the United States Army Signal Corps, the USAF was established as a separate branch of the United States Armed Forces in 1947 with the enactment of the National Security Act of 1947. It is the second youngest branch of the United States Armed Forces and the fourth in order of precedence. The United States Air Force articulates its core missions as air supremacy, global integrated intelligence, surveillance and reconnaissance, rapid global mobility, global strike, and command and control. The United States Air Force is a military service branch organized within the Department of the Air Force, one of the three military departments of the Department of Defense. The Air Force through the Department of the Air Force is headed by the civilian Secretary of the Air Force ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brooks Air Force Base
Brooks Air Force Base was a United States Air Force facility located in San Antonio, Texas, southeast of Downtown San Antonio. In 2002, Brooks Air Force Base was renamed Brooks City-Base when the property was conveyed to the Brooks Development Authority as part of a unique project between local, state, and federal government. The Brooks Development Authority is now the owner and operator of the property, and is redeveloping it as a science, business, and technology center. The Air Force was the largest tenant at Brooks City-Base. Units Major units * 311th Air Base Group * 311th Human Systems Wing Tenant units * Air Force Audit Agency * Air Force Research Laboratory History On February 16, 1918, Kelly Field No. 5 became a separate post and named Brooks Field by the Aviation Section, U.S. Signal Corps to honor San Antonio aviator Sidney Johnson Brooks, Jr. The first commander of Brooks Field was Lt. Col. H. Conger Pratt, who until the preceding October had been a cavalr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fritz Lipmann
Fritz Albert Lipmann (; June 12, 1899 – July 24, 1986) was a German-American biochemist and a co-discoverer in 1945 of coenzyme A. For this, together with other research on coenzyme A, he was awarded the Nobel Prize in Physiology or Medicine in 1953 (shared with Hans Adolf Krebs). Early life and education Lipmann was born in Königsberg, Germany, to a Jewish family. His parents were Gertrud (Lachmanski) and Leopold Lipmann, an attorney. Lipmann studied medicine at the University of Königsberg, Berlin, and Munich, graduating in Berlin in 1924. He returned to Königsberg to study chemistry under Professor Hans Meerwein. In 1926 he joined Otto Meyerhof at the Kaiser Wilhelm Institute for Biology, Dahlem, Berlin, for his doctoral thesis. After that he followed Meyerhof to Heidelberg to the Kaiser Wilhelm Institute for Medical Research. Career From 1939 on, Lipmann lived and worked in the United States. He was a Research Associate in the Department of Biochemistry, Cornell Univer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein ( substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. There are two main types of protein kinase. The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets and most of the others are tyrosine kinases, although additional types exist. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction. Chemical ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms ( palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals ( signal transduction). The development of therapies with specific molecular or genetic targets, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response. Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway. When signaling pathways interact with one another they form networks, which allow cellular responses to be coordinated, often by combinatorial signaling events. At the molecular level, such responses include changes in the transcription or translation of genes, and post-translational and conformational changes in proteins, as well as changes in their location. These molecular events are the basic mechanisms controlling cell growth, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
