Robert L. Hill (biochemist)
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Robert L. Hill (1928-2012) was a
biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
who spent most of his career on the faculty at
Duke University School of Medicine The Duke University School of Medicine, commonly known as Duke Med, is the medical school of Duke University. It is located in the Collegiate Gothic-style West Campus of Duke University in Durham, North Carolina. The School of Medicine, along wit ...
, from which he retired as the
James B. Duke James Buchanan Duke (December 23, 1856 – October 10, 1925) was an American tobacco and electric power industrialist best known for the introduction of modern cigarette manufacture and marketing, and his involvement with Duke Universit ...
Professor Emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
. Hill's research focused on the chemistry of
enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
s, with particular specialization in glycosyltransferases and
glycobiology Defined in the narrowest sense, glycobiology is the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature. Sugars or saccharides are essential components of all living thing ...
. Hill was elected to the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
in 1974, the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
in 1975, the
Institute of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, E ...
in 1978. He served on the editorial board of the
scientific journal In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. Content Articles in scientific journals are mostly written by active scientists such as s ...
''
Journal of Biological Chemistry The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in ...
'' beginning in 1965 and as associate editor from 1988 to 2012, where he initiated a regular feature series called "Classics" in which the journal reprinted selected papers of high historical significance. Hill died on November 29, 2012.


Early life and education

Hill was born in
Kansas City, Missouri Kansas City (abbreviated KC or KCMO) is the largest city in Missouri by population and area. As of the 2020 census, the city had a population of 508,090 in 2020, making it the 36th most-populous city in the United States. It is the central ...
in 1928. He was an undergraduate at the
University of Kansas The University of Kansas (KU) is a public research university with its main campus in Lawrence, Kansas, United States, and several satellite campuses, research and educational centers, medical centers, and classes across the state of Kansas. Tw ...
and received a B.S. in chemistry in 1949. He remained there for graduate work under the supervision of Russell Mills, and received his Ph.D. in 1954. He then worked as a
postdoctoral fellow A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...
at the
University of Utah The University of Utah (U of U, UofU, or simply The U) is a public research university in Salt Lake City, Utah. It is the flagship institution of the Utah System of Higher Education. The university was established in 1850 as the University of De ...
with
Emil L. Smith Emil L. Smith (July 5, 1911 – May 31, 2009) was an American biochemist who studied protein structure and function as well as biochemical evolution. Initially intending to go into medicine, Smith became interested in biology and organic c ...
.


Academic career

Hill joined the faculty at the
University of Utah The University of Utah (U of U, UofU, or simply The U) is a public research university in Salt Lake City, Utah. It is the flagship institution of the Utah System of Higher Education. The university was established in 1850 as the University of De ...
in 1956.
Philip Handler Philip Handler (August 13, 1917 – December 29, 1981) was an American nutritionist, and biochemist. He was President of the United States National Academy of Sciences for two terms from 1969 to 1981. He was also a recipient of the National Meda ...
, then chair of the biochemistry department at
Duke University School of Medicine The Duke University School of Medicine, commonly known as Duke Med, is the medical school of Duke University. It is located in the Collegiate Gothic-style West Campus of Duke University in Durham, North Carolina. The School of Medicine, along wit ...
, recruited Hill to move to Duke. Hill moved in 1961 and remained at Duke for the rest of his career. He was named to the
James B. Duke James Buchanan Duke (December 23, 1856 – October 10, 1925) was an American tobacco and electric power industrialist best known for the introduction of modern cigarette manufacture and marketing, and his involvement with Duke Universit ...
professorship in 1965 and served as department chair from 1969 to 1993, succeeding Handler after the latter assumed the presidency of the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
. Hill was active in service and leadership roles in scientific societies, particularly the American Society for Biochemistry and Molecular Biology, of which he was president in 1976. He served on the editorial boards of several journals and had a particularly long association with the ''
Journal of Biological Chemistry The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in ...
''. He joined the editorial board in 1965 and became associate editor in 1988, a role he kept after his retirement from Duke and until shortly before his death in 2012. At JBC he initiated and co-curated the JBC Classics series, which reprinted papers from the journal archives of particularly high scientific impact. Along with Smith and Handler, Hill co-edited a foundational textbook in biochemistry from 1968 to 1978.


Research

Hill developed an interest in protein chemistry during his postdoctoral work and became known for his studies of
hemoglobin Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...
while at Utah. He made major contributions to the study of
immunoglobulin An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
structure and was particularly influential in the field of
glycobiology Defined in the narrowest sense, glycobiology is the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature. Sugars or saccharides are essential components of all living thing ...
, which became a major focus of his work after he and collaborating scientists discovered that lactose synthetase contains a glycosyltransferase enzyme.


Awards and honors

* Elected to the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
, 1974 * Elected to the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
, 1975 * Elected to the
Institute of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, E ...
, 1978 * Received the North Carolina Gold Medal in 1985 * Received the American Society for Biochemistry and Molecular Biology's
William C. Rose Award The William C. Rose Award given by the American Society for Biochemistry and Molecular Biology recognizes outstanding contributions to biochemical and molecular biological research and a demonstrated commitment to the training of younger scientists ...
, 2001 * Received the Society for Glycobiology's Karl Meyer Award, 2001


References


External links


2010 Duke Medicine Emeriti - Robert L. Hill, PhD
2010 interview with Hill {{DEFAULTSORT:Hill, Robert L. University of Kansas alumni Duke University faculty Fellows of the American Academy of Arts and Sciences Members of the United States National Academy of Sciences Members of the National Academy of Medicine 1928 births 2012 deaths American biochemists Biologists from Missouri