Richard H. Scheller (born 30 October 1953) is the former Chief Science Officer and Head of Therapeutics at
23andMe
23andMe Holding Co. is a publicly held personal genomics and biotechnology company based in South San Francisco, California. It is best known for providing a direct-to-consumer genetic testing service in which customers provide a saliva sample t ...
and the former Executive Vice President of Research and Early Development at
Genentech
Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within R ...
.
He was a professor at
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
from 1982 to 2001 before joining Genentech. He has been awarded the
Alan T. Waterman Award
The Alan T. Waterman Award, named after Alan Tower Waterman, is the United States's highest honorary award for scientists no older than 40, or no more than 10 years past receipt of their Ph.D. It is awarded on a yearly basis by the National Scien ...
in 1989, the W. Alden Spencer Award in 1993 and the
NAS Award in Molecular Biology
The NAS Award in Molecular Biology is awarded by the U.S. National Academy of Sciences "for recent notable discovery in molecular biology by a young scientist who is a citizen of the United States." It has been awarded annually since its inceptio ...
in 1997, won the 2010
Kavli Prize
The Kavli Prize was established in 2005 as a joint venture of the Norwegian Academy of Science and Letters, the Norwegian Ministry of Education and Research, and the Kavli Foundation. It honors, supports, and recognizes scientists for outstand ...
in Neuroscience with
Thomas C. Südhof
Thomas Christian Südhof (; born December 22, 1955), ForMemRS, is a German-American biochemist known for his study of synaptic transmission. Currently, he is a professor in the School of Medicine in the Department of Molecular and Cellular P ...
and
James E. Rothman, and won the 2013
Albert Lasker Award for Basic Medical Research
The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...
with Thomas Südhof. He was also given the Life Sciences Distinguished Alumni Award from
University of Wisconsin–Madison
The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin. Founded when Wisconsin achieved statehood in 1848, UW–Madison ...
. He is a Fellow of the
American Academy of Arts and Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
and a Member of the
National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
.
Biography
He earned his
B.S.
A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years.
The first university to admit a student to the degree of Bachelor of Science was the University ...
in
biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
from the University of Wisconsin–Madison and his Ph.D. in
chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
from the
California Institute of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
under the guidance of
Eric H. Davidson. While a graduate student, he worked with Keiichi Itakura and
Arthur Riggs to help synthesize
Somatostatin
Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-couple ...
for
Herb Boyer at Genentech.
After finishing his graduate studies, he did a brief postdoc with Davidson and later with
Eric Kandel
Eric Richard Kandel (; born Erich Richard Kandel, November 7, 1929) is an Austrian-born American medical doctor who specialized in psychiatry, a neuroscientist and a professor of biochemistry and biophysics at the College of Physicians and Surge ...
and
Richard Axel
Richard Axel (born July 2, 1946) is an American molecular biologist and university professor in the Department of Neuroscience at Columbia University and investigator at the Howard Hughes Medical Institute. His work on the olfactory system won hi ...
at
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
.
While at Columbia, he extended his previous work with recombinant DNA to identify the egg-laying hormone (ELH) gene family of neuropeptides.
Scheller joined the Stanford University faculty in the Department of Biological Sciences in 1982 and later the Department of Molecular and Cellular Physiology. He was an investigator with the
Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...
from 1990 to 2001.
While at Stanford, he cloned and identified the proteins that control neurotransmitter release notably those in the
Syntaxin
Syntaxins are a family of membrane integrated Q-SNARE proteins participating in exocytosis.
Domains
Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain (known as H3), and an N-terminal regulatory domain (Habc).
Syntaxin ...
family of transport proteins,
Rab GTPases, and
SNAREs.
In 2001, he was recruited from Stanford to join Genentech as a Senior Vice President and Chief Research Officer replacing Dennis Henner. In 2008, was named the Chief Scientific Officer and Executive Vice President of Research. After the acquisition of Genentech by
Hoffmann-La Roche
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX ...
, he was appointed the Head of Genentech Research and Early Development and a member of the enlarged Roche Corporate Executive Committee. He is concurrently an Adjunct Professor in the Department of Biochemistry and Biophysics at the
University of California San Francisco
The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It condu ...
.
In March 2015, Scheller joined 23andMe as the Chief Scientific Officer and Head of Therapeutics, creating and leading their
Therapeutics
A therapy or medical treatment (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a medical diagnosis.
As a rule, each therapy has indications and contraindications. There are many different ...
team, which translates genetic data into discovery and development of new drug therapies.
Scheller is also known as an expert and enthusiastic collector of traditional and historical African Art, since the 1980s. An article about his passion for African Art appeared in Tribal Arts Magazine and some of his extensive collection was exhibited and published with the 2015 show entitled "Embodiments" at the De Young Museum in San Francisco.
Awards
*1989 –
Alan T. Waterman Award
The Alan T. Waterman Award, named after Alan Tower Waterman, is the United States's highest honorary award for scientists no older than 40, or no more than 10 years past receipt of their Ph.D. It is awarded on a yearly basis by the National Scien ...
*1993 –
W. Alden Spencer Award
The W. Alden Spencer Award is awarded to an investigator in recognition of outstanding research contributions by the Columbia University College of Physicians and Surgeons, College of Physicians and Surgeons, the Department of Neuroscience, and T ...
*1997 –
NAS Award in Molecular Biology
The NAS Award in Molecular Biology is awarded by the U.S. National Academy of Sciences "for recent notable discovery in molecular biology by a young scientist who is a citizen of the United States." It has been awarded annually since its inceptio ...
*Life Sciences Distinguished Alumni Award from
University of Wisconsin-Madison
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the ...
*2010 –
Kavli Prize
The Kavli Prize was established in 2005 as a joint venture of the Norwegian Academy of Science and Letters, the Norwegian Ministry of Education and Research, and the Kavli Foundation. It honors, supports, and recognizes scientists for outstand ...
in Neuroscience
*2013 –
Albert Lasker Award for Basic Medical Research
The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...
*2014 – Distinguished Alumni Award from
California Institute of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
*2015 –
National Academies of Science
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Natio ...
*Fellow of the
Norwegian Academy of Science and Letters
The Norwegian Academy of Science and Letters ( no, Det Norske Videnskaps-Akademi, DNVA) is a learned society based in Oslo, Norway. Its purpose is to support the advancement of science and scholarship in Norway.
History
The Royal Frederick Univer ...
Personal life
He is married to
Susan McConnell, a Professor in the Department of Biology at Stanford University and lives on Stanford Campus.
References
External links
23andMe BioGenentech BioInterview from Bancroft Library
{{DEFAULTSORT:Scheller, Richard
1953 births
Living people
American neuroscientists
Howard Hughes Medical Investigators
Genentech people
Members of the United States National Academy of Sciences
University of Wisconsin–Madison College of Letters and Science alumni
California Institute of Technology alumni
Scientists from Milwaukee
University of California, San Francisco faculty
Stanford University Department of Biology faculty
Stanford University School of Medicine faculty
Recipients of the Albert Lasker Award for Basic Medical Research
Members of the Norwegian Academy of Science and Letters
Kavli Prize laureates in Neuroscience