Rhodanine is a 5-membered
heterocyclic organic compound possessing a
thiazolidine core. It was discovered in 1877 by
Marceli Nencki who named it ''"Rhodaninsaure"'' in reference to its synthesis from ammonium rhodanide (known as
ammonium thiocyanate to modern chemists) and
chloroacetic acid in water.
Rhodanines can also be prepared by the reaction of
carbon disulfide,
ammonia, and
chloroacetic acid, which proceeds via an intermediate
dithiocarbamate.
:
Derivatives
Some rhodanine
derivatives
The derivative of a function is the rate of change of the function's output relative to its input value.
Derivative may also refer to:
In mathematics and economics
* Brzozowski derivative in the theory of formal languages
* Formal derivative, an ...
have pharmacological properties; for instance,
epalrestat
Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. ...
is used to treat
diabetic neuropathy
Diabetic neuropathy is various types of nerve damage associated with diabetes mellitus. Symptoms depend on the site of nerve damage and can include motor changes such as weakness; sensory symptoms such as numbness, tingling, or pain; or autonomic c ...
. However, most are promiscuous binders with poor selectivity; as a result, this class of compounds is viewed with suspicion by medicinal chemists. Differing academic opinions exist concerning the correct use of
PAINS filters, the necessity of the experimental confirmations of such properties, and many useful features of rhodanine derivatives.
References
{{reflist
Thiazolidines
Lactams