Rhapontigenin is a
stilbenoid
Stilbenoids are hydroxylated derivatives of stilbene. They have a C6–C2–C6 structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Most stilbenoids are prod ...
. It can be isolated from ''
Vitis coignetiae
''Vitis coignetiae'', called crimson glory vine, is a plant belonging to the genus ''Vitis'' that is native to the temperate climes of Asia, where it can be found in the Russian Far East, (Sakhalin); Korea; and Japan (Hokkaido, Honshu, Shikoku). ...
'' or from ''
Gnetum cleistostachyum
''Gnetum cleistostachyum'' is a liana species in the ''Sessiles'' subsection of the genus ''Gnetum'' described from South East Yunnan.
The name is still invalid and efloras states it is advisable to postpone validating it until more complete c ...
''.
It shows an action on
prostate cancer
Prostate cancer is cancer of the prostate. Prostate cancer is the second most common cancerous tumor worldwide and is the fifth leading cause of cancer-related mortality among men. The prostate is a gland in the male reproductive system that sur ...
cells. It has been shown to inhibit the human
cytochrome P450 1A1, an enzyme implicated in the biotransformation of a number of carcinogenic and immunotoxic compounds.
Injected in rats, rhapontigenin shows a rapid
glucuronidation
Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosid ...
and a poor
bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.
By definition, when a medication is administered intravenously, its bioavailability is 100%. H ...
.
See also
*
Rhaponticin
Rhaponticin is a stilbenoid glucoside compound. Its aglycone is called rhapontigenin. It can be found in rhubarb rhizomes.
It has beneficial effects on diabetic mice, and ''in vitro'' results suggest it may be relevant to Alzheimer's disease with ...
, its glucoside, found in rhubarb.
*
Isorhapontigenin
Isorhapontigenin is a tetrahydroxylated stilbenoid with a methoxy group. It is an isomer of rhapontigenin and an analog of resveratrol. It is found in the Chinese herb ''Gnetum cleistostachyum'', in ''Gnetum parvifolium'' and in the seeds of the pa ...
, a structural isomer.
References
External links
*
Stilbenoids
Cytochrome P450 inhibitors
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