''Respirovirus'' is a genus of

virus A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1 ...

es in the order ''

Mononegavirales ''Mononegavirales'' is an order of negative-strand RNA viruses which have nonsegmented genomes. Some common members of the order are Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of ...

'', in the family ''

Paramyxoviridae ''Paramyxoviridae'' (from Ancient Greek, Greek ''para-'' “by the side of” and ''myxa'' “mucus”) is a family of negative-strand RNA viruses in the order ''Mononegavirales''. Vertebrates serve as natural hosts. Diseases associated with this ...

''. Rodents and human serve as natural hosts. There are seven species in this genus. Diseases associated with this genus include:

croup Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused by a virus. The infection leads to swelling inside the trachea, which interferes with normal breathing and produces the classic symptoms o ...

and other acute febrile respiratory tract infections.

Structure

Respirovirions are enveloped, with spherical geometries. The diameter is around 150 nm. Respirovirus genomes are linear, around 15kb in length. The genome codes for 8 proteins.

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by virus attaches to host cell. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. Translation takes place by leaky scanning, and

ribosomal shunting Ribosome shunting is a mechanism of translation initiation in which ribosomes bypass, or "shunt over", parts of the 5' untranslated region to reach the start codon. However, a benefit of ribosomal shunting is that it can translate backwards allowi ...

. The virus exits the host cell by budding. Rodents and human serve as the natural host. Transmission routes are respiratory.

References

External links

ICTV Report: ''Paramyxoviridae''

{{Use dmy dates, date=April 2017 Virus genera Paramyxoviridae