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Reactive carbonyl species (RCS) are molecules with highly reactive
Reactive carbonyl species (RCS) are molecules with highly reactive carbonyl
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C=O. It is common to several classes of organic compounds, as part of many larger functional groups. A compound containing a ...
groups, and often known for their damaging effects on proteins, nucleic acids, and lipids. They are often generated as metabolic products. Important RCSs include 3-deoxyglucosone, glyoxal
Glyoxal is an organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of ...
, and methylglyoxal
Methylglyoxal (MGO) is the organic compound with the formula CH3C(O)CHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation ...
. RCSs react with amines and thiol groups leading to advanced glycation endproduct
Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases, such as diabetes, at ...
s (AGEs). AGE's are indicators of diabetes.
Reactive aldehyde species (RASP), such as malondialdehyde
Malondialdehyde (MDA) is the organic compound with the nominal formula CH2(CHO)2. A colorless liquid, malondialdehyde is a highly reactive compound that occurs as the enol. It occurs naturally and is a marker for oxidative stress.
Structure and ...
and 4-hydroxynonenal
4-Hydroxynonenal, or 4-hydroxy-2-nonenal or 4-HNE or HNE, (), is an α,β-unsaturated hydroxyalkenal that is produced by lipid peroxidation in cells. 4-HNE is the primary α,β-unsaturated hydroxyalkenal formed in this process. It is a colorless ...
, are a subset of RCS that are implicated in a variety of human diseases.
See also
*Reactive oxygen species
In chemistry, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen (). Examples of ROS include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
The reduction of molecular oxygen () p ...
* Reactive sulfur species Reactive sulfur species (RSS) are a family of sulfur-based chemical compounds that can oxidize and inhibit thiol-proteins and enzymes. They are often formed by the oxidation of thiols and disulfides into higher oxidation states. Examples of RSS incl ...
* Reactive nitrogen species
Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (•NO) and superoxide (O2•−) produced via the enzymatic activity of inducible nitric oxide synthase 2 ( NOS2) and NADPH oxidase respectivel ...
References
Molecules Carbon compounds {{Biochemistry-stub