Raymond J. St. Leger (born 1957, in London, England) is an American

mycologist Mycology is the branch of biology concerned with the study of fungus, fungi, including their genetics, genetic and biochemistry, biochemical properties, their Taxonomy (biology), taxonomy and ethnomycology, their use to humans, including as a so ...

entomologist Entomology () is the scientific study of insects, a branch of zoology. In the past the term "insect" was less specific, and historically the definition of entomology would also include the study of animals in other arthropod groups, such as arach ...

molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

and

biotechnologist Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...

who currently holds the rank of Distinguished University Professor in the Department of

Entomology Entomology () is the science, scientific study of insects, a branch of zoology. In the past the term "insect" was less specific, and historically the definition of entomology would also include the study of animals in other arthropod groups, such ...

(https://entomology.umd.edu/) at the

University of Maryland, College Park The University of Maryland, College Park (University of Maryland, UMD, or simply Maryland) is a public land-grant research university in College Park, Maryland. Founded in 1856, UMD is the flagship institution of the University System of Mary ...

Research and career

St. Leger went to the

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...

to begin his career at the

Boyce Thompson Institute The Boyce Thompson Institute (previously: Boyce Thompson Institute for Plant Research) is an independent research institute devoted to using plant sciences to improve agriculture, protect the Environment (biophysical), environment, and enhance hea ...

at the invitation of Donald W. Roberts. According to

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Released in beta in November 2004, the Google Scholar index includes p ...

, he has since then published more than 150 scientific papers and book chapters on

fungal A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from th ...

pathogens In biology, a pathogen ( el, πάθος, "suffering", "passion" and , "producer of") in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a germ ...

plants Plants are predominantly Photosynthesis, photosynthetic eukaryotes of the Kingdom (biology), kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all curr ...

animals Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia. With few exceptions, animals consume organic material, breathe oxygen, are able to move, can reproduce sexually, and go through an ontogenetic stage in ...

and

insects Insects (from Latin ') are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body (head, thorax and abdomen), three pairs of j ...

, and on the reactions of hosts to

infection An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...

. St. Leger has principally used

entomopathogenic fungus An entomopathogenic fungus is a fungus that can kill or seriously disable insects. Typical life cycle These fungi usually attach to the external body surface of insects in the form of microscopic spores (usually asexual, mitosporic spores also ...

(

fungi A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from ...

that act as

parasite Parasitism is a close relationship between species, where one organism, the parasite, lives on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The entomologist E. O. Wilson has ...

s of

), as models for understanding how

in general respond to stress, changing

environments Environment most often refers to: __NOTOC__ * Natural environment, all living and non-living things occurring naturally * Biophysical environment, the physical and biological factors along with their chemical interactions that affect an organism or ...

, initiate host invasion, colonize tissues, and counter host

immune In biology, immunity is the capability of multicellular organisms to resist harmful microorganisms. Immunity involves both specific and nonspecific components. The nonspecific components act as barriers or eliminators of a wide range of pathogens ...

responses. These investigations have also addressed the mechanisms by which new pathogens emerge with different host ranges and genetic variation between individuals in host defenses. Other interests include fungal and insect

behavior Behavior (American English) or behaviour (British English) is the range of actions and mannerisms made by individuals, organisms, systems or artificial entities in some environment. These systems can include other systems or organisms as wel ...

and

evolution Evolution is change in the heritable characteristics of biological populations over successive generations. These characteristics are the expressions of genes, which are passed on from parent to offspring during reproduction. Variation ...

, molecular biology and genomics of fungi, and mutualistic associations between microbes and plants that can be exploited to benefit

agriculture Agriculture or farming is the practice of cultivating plants and livestock. Agriculture was the key development in the rise of sedentary human civilization, whereby farming of domesticated species created food surpluses that enabled people to ...

. St. Leger is also known for developing

transgenic A transgene is a gene that has been transferred naturally, or by any of a number of genetic engineering techniques, from one organism to another. The introduction of a transgene, in a process known as transgenesis, has the potential to change the ...

technologies, including altering insect pathogens so that they carry genes encoding

spider Spiders ( order Araneae) are air-breathing arthropods that have eight legs, chelicerae with fangs generally able to inject venom, and spinnerets that extrude silk. They are the largest order of arachnids and rank seventh in total species ...

and

scorpion Scorpions are predatory arachnids of the order Scorpiones. They have eight legs, and are easily recognized by a pair of grasping pincers and a narrow, segmented tail, often carried in a characteristic forward curve over the back and always end ...

toxins. A field trial in

Burkina Faso Burkina Faso (, ; , ff, 𞤄𞤵𞤪𞤳𞤭𞤲𞤢 𞤊𞤢𞤧𞤮, italic=no) is a landlocked country in West Africa with an area of , bordered by Mali to the northwest, Niger to the northeast, Benin to the southeast, Togo and Ghana to the ...

has shown that these engineered pathogens have the potential to control insect borne diseases such as

malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...

. St. Leger has tested an array of "alternative engineering strategies to be consistent with the highly exploratory approach required for optimizing a pathogens

biocontrol Biological control or biocontrol is a method of controlling pests, such as insects, mites, weeds, and plant diseases, using other organisms. It relies on predation, parasitism, herbivory, or other natural mechanisms, but typically also invo ...

potential". For example, engineering a mosquito pathogenic fungus to carry a gene for a human anti-malarial antibody so that the fungus targets the malarial parasite in the mosquito reduces the possibility of mosquitoes evolving resistance to the fungus. St. Leger has been a consultant on

biotechnology Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...

to many private and public concerns, including the

NIH The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

, the

USDA The United States Department of Agriculture (USDA) is the federal executive department responsible for developing and executing federal laws related to farming, forestry, rural economic development, and food. It aims to meet the needs of com ...

, the

NSF NSF may stand for: Political organizations *National Socialist Front, a Swedish National Socialist party *NS-Frauenschaft, the women's wing of the former German Nazi party *National Students Federation, a leftist Pakistani students' political gr ...

, the

US State Department The United States Department of State (DOS), or State Department, is an executive department of the U.S. federal government responsible for the country's foreign policy and relations. Equivalent to the ministry of foreign affairs of other nati ...

and the

Organization of American States The Organization of American States (OAS; es, Organización de los Estados Americanos, pt, Organização dos Estados Americanos, french: Organisation des États américains; ''OEA'') is an international organization that was founded on 30 April ...

. St. Leger has also served on many national and international policy-making committees including the

Bill Gates William Henry Gates III (born October 28, 1955) is an American business magnate and philanthropist. He is a co-founder of Microsoft, along with his late childhood friend Paul Allen. During his career at Microsoft, Gates held the positions ...

funded National Academies Committee to study technologies to benefit

Sub Saharan Africa Sub-Saharan Africa is, geographically, the area and regions of the continent of Africa that lies south of the Sahara. These include West Africa, East Africa, Central Africa, and Southern Africa. Geopolitically, in addition to the African co ...

and

South Asia South Asia is the southern subregion of Asia, which is defined in both geographical and ethno-cultural terms. The region consists of the countries of Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka.;;;;;;;; ...

(2009). St. Leger is an advocate of online open education and since 2013 has co-taught with Dr. Tammatha O’Brien (https://tammatha.weebly.com/) a

MOOC A massive open online course (MOOC ) or an open online course is an online course aimed at unlimited participation and open access via the Web. In addition to traditional course materials, such as filmed lectures, readings, and problem sets, m ...

on the

Coursera Coursera Inc. () is a U.S.-based massive open online course provider founded in 2012 by Stanford University computer science professors Andrew Ng and Daphne Koller. Coursera works with universities and other organizations to offer online courses, ...

platform called Genes and the Human Condition that has had more than 200,000 active learners.

Education

St. Leger received his

Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of ...

in biology from

Exeter University , mottoeng = "We Follow the Light" , established = 1838 - St Luke's College1855 - Exeter School of Art1863 - Exeter School of Science 1955 - University of Exeter (received royal charter) , type = Public , ...

England England is a country that is part of the United Kingdom. It shares land borders with Wales to its west and Scotland to its north. The Irish Sea lies northwest and the Celtic Sea to the southwest. It is separated from continental Europe b ...

in 1978, a

Master of Science A Master of Science ( la, Magisterii Scientiae; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree in the field of science awarded by universities in many countries or a person holding such a degree. In contrast to ...

entomology Entomology () is the science, scientific study of insects, a branch of zoology. In the past the term "insect" was less specific, and historically the definition of entomology would also include the study of animals in other arthropod groups, such ...

in 1980 from

Birkbeck College Birkbeck, University of London (formally Birkbeck College, University of London), is a public university, public research university, located in Bloomsbury, London, England, and a constituent college, member institution of the federal Universit ...

London University The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degree- ...

, and a

Doctor of Philosophy A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common Academic degree, degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields ...

in 1985 from the

University of Bath (Virgil, Georgics II) , mottoeng = Learn the culture proper to each after its kind , established = 1886 (Merchant Venturers Technical College) 1960 (Bristol College of Science and Technology) 1966 (Bath University of Technology) 1971 (univ ...

Awards and honors

St. Leger has received several awards for his research, he was elected a

fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...

of the AAAS (2012), the

American Academy of Microbiology The American Society for Microbiology (ASM), originally the Society of American Bacteriologists, is a professional organization for scientists who study viruses, bacteria, fungi, algae, and protozoa as well as other aspects of microbiology. It wa ...

(2013), the

Royal Entomological Society of London The Royal Entomological Society is devoted to the study of insects. Its aims are to disseminate information about insects and improving communication between entomologists. The society was founded in 1833 as the Entomological Society of London ...

(FRES) (2011), the

Entomological Society of America The Entomological Society of America (ESA) was founded in 1889 and today has more than 7,000 members, including educators, extension personnel, consultants, students, researchers, and scientists from agricultural departments, health agencies, ...

(2019) and is a

Fellow of the Royal Society of Biology Fellowship of the Royal Society of Biology (FRSB), previously Fellowship of the Society of Biology (FSB), is an award and fellowship granted to individuals that the Royal Society of Biology has adjudged to have made a "prominent contribution to ...

(FRSB). He received the

American Society for Microbiology The American Society for Microbiology (ASM), originally the Society of American Bacteriologists, is a professional organization for scientists who study viruses, bacteria, fungi, algae, and protozoa as well as other aspects of microbiology. It ...

Promega Biotechnology Research Award (2017) and was the inaugural recipient of the Tai Fung-Lan Award for International Cooperation from The Mycological Society of China (2016). St. Leger received an honorary

doctorate A doctorate (from Latin ''docere'', "to teach"), doctor's degree (from Latin ''doctor'', "teacher"), or doctoral degree is an academic degree awarded by universities and some other educational institutions, derived from the ancient formalism ''l ...

from his alma mater of

in 2018 and the

Newcomb Cleveland Prize The Newcomb Cleveland Prize of the American Association for the Advancement of Science (AAAS) is annually awarded to author(s) of outstanding scientific paper published in the Research Articles or Reports sections of ''Science''. Established in 192 ...

for the most impactful paper published in the journal Science in 2019. St. Leger gave the Founders lecture at the 2009 Society of Invertebrate Pathology Meeting honoring his friend and frequent collaborator Donald W. Roberts.

Selected bibliography

* *

References

External links

The St. Leger Lab
{{DEFAULTSORT:St. Leger, Raymond 1957 births Living people 21st-century American biologists British emigrants to the United States Alumni of the University of Exeter Alumni of the University of Bath Scientists from London University of Maryland, College Park faculty American mycologists American entomologists

Raymond Raymond is a male given name. It was borrowed into English from French (older French spellings were Reimund and Raimund, whereas the modern English and French spellings are identical). It originated as the Germanic ᚱᚨᚷᛁᚾᛗᚢᚾᛞ ( ...