Retinoic acid early inducible 1 (RAE-1) family of murine cell surface

glycoprotein Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...

s is composed of at least five members (RAE-1α-ε). Genes encoding these proteins are located on mouse chromosome 10. RAE-1 proteins are related to

MHC class I MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of vertebrates. They also occur on plat ...

, they are made up of external α1α2 domain which is linked to the cell membrane by the GPI anchor. They function as stress-induced ligands for

NKG2D NKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin, C-type lectin-like receptors. NKG2D is encoded by ''KLRK1'' (killer cell lectin like receptor K1) gene which is located in the NK-gene complex ...

receptor and their expression is low or absent on normal cells. However, they are constitutively expressed on some tumour cells and they can be upregulated by

retinoic acid Retinoic acid (used simplified here for all-''trans''-retinoic acid) is a metabolite of vitamin A1 (all-''trans''-retinol) that mediates the functions of vitamin A1 required for growth and development. All-''trans''-retinoic acid is required in ...

References

{{reflist Glycoproteins Immunology