Regulator of G-protein signaling 7 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''RGS7''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled
GPCR
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
. RGS7 is a
GTPase-activating protein GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GAPs are a ...
(GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.
Interactions
RGS7 has been shown to
interact
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with:
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GNB5
Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the ''GNB5'' gene. Alternatively spliced transcript variants encoding different isoforms exist.
Function
Heterotrimeric guanine nucleotide-binding prote ...
,
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GPR158
Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the ''GPR158'' gene.
Function
This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled ...
,
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GPR179
Probable G-protein coupled receptor 179 is a protein that in humans is encoded by the ''GPR179'' gene.
Clinical relevance
Mutations in this gene have been associated to cases of congenital stationary Night Blindness.
References
Further read ...
,
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PKD1
Polycystin 1 (often abbreviated to PC1) is a protein that in humans is encoded by the ''PKD1'' gene. Mutations of ''PKD1'' are associated with most cases of autosomal dominant polycystic kidney disease, a severe hereditary disorder of the kidneys ...
,
and
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SNAPAP
SNARE-associated protein Snapin is a protein that in humans is encoded by the ''SNAPIN'' gene.
Function
SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a component ...
.
References
Further reading
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