RING-box protein 1 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''RBX1''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

This gene encodes an evolutionarily conserved protein that interacts with

cullin Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form ''Cullin-RING ubiquitin ligases'' (CRLs) that are highly dive ...

s. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.

Interactions

RBX1 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with: *

CAND1 Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the ''CAND1'' gene. Interactions CAND1 has been shown to interact with: * CUL1, * CUL2, * CUL3, * CUL4A, * CUL4B, * DCUN1D1 DCN1-like protein 1 is a ...

, * CUL1, *

CUL2 Cullin-2 is a protein that in humans is encoded by the ''CUL2'' gene. Interactions CUL2 has been shown to interact with: * CAND1, * DCUN1D1, * RBX1, * SAP130, * TCEB2 and * Von Hippel-Lindau tumor suppressor The term ''von'' () ...

, *

CUL4A Cullin-4A is a protein that in humans is encoded by the ''CUL4A'' gene. CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chro ...

, *

CUL5 Cullin-5 is a protein that in humans is encoded by the ''CUL5'' gene. Discovery The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide ...

CUL7 Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the ''CUL7'' gene. Clinical significance It is associated with 3-M syndrome. Interactions CUL7 has been shown to interact with RBX1 RING-box protein 1 is a protein that in hum ...

, *

DCUN1D1 DCN1-like protein 1 is a protein that in humans is encoded by the ''DCUN1D1'' gene. DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells. Interactions DCUN1D1 has bee ...

, and *

P70-S6 Kinase 1 Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the ''RPS6KB1'' gene. It is a serine/threonine kinase that acts downstream of PIP3 ...

Function

Interactions

References

Further reading