Pipotiazine (Piportil), also known as pipothiazine, is a

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics ma ...

of the

phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. T ...

class used in the

United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and North ...

and other countries for the treatment of

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...

. Its properties are similar to those of

chlorpromazine Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar dis ...

. A 2004

systematic review A systematic review is a Literature review, scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from publ ...

investigated its efficacy for people with schizophrenia:

Synthesis

The alkylation of 2-Dimethylaminosulfonylphenthiazine 090-78-4(1) with

1-Bromo-3-chloropropane 1-Bromo-3-chloropropane is an organohalogen compound with the formula Br(CH2)3Cl. It is a colorless liquid, produced by free-radical addition of hydrogen bromide to allyl chloride. It is used as an alkylating agent to install the –(CH2)3Cl an ...

(2) gives 10-(3-chloropropyl)-N,N-dimethylphenothiazine-2-sulfonamide 0051-12-5(3). Alkylation with 4-Piperidineethanol 22-26-4(4) completes the synthesis of ''Pipothiazine'' (5).

References

Phenothiazines Typical antipsychotics Piperazines Primary alcohols Sulfonamides Dimethylamino compounds {{nervous-system-drug-stub

Synthesis

See also

References