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Peter Oehme (born 5 June 1937) is a German physician and pharmacologist. In 1977 he founded the
East German East Germany, officially the German Democratic Republic (GDR; german: Deutsche Demokratische Republik, , DDR, ), was a country that existed from its creation on 7 October 1949 until its dissolution on 3 October 1990. In these years the state ...
Drugs Research Institute, serving as its director from January 1977 till December 1991 when the institute was reconfigured in the context of
German reunification German reunification (german: link=no, Deutsche Wiedervereinigung) was the process of re-establishing Germany as a united and fully sovereign state, which took place between 2 May 1989 and 15 March 1991. The day of 3 October 1990 when the Ge ...
.


Life

Peter Oehme was born in
Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...
. During the war years
Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...
was subject to heavy air-raids and he was evacuated, with his mother, to a village in
Saxony Saxony (german: Sachsen ; Upper Saxon: ''Saggsn''; hsb, Sakska), officially the Free State of Saxony (german: Freistaat Sachsen, links=no ; Upper Saxon: ''Freischdaad Saggsn''; hsb, Swobodny stat Sakska, links=no), is a landlocked state of ...
. US troops invaded and then withdrew from the area in the summer of 1945, reflecting an agreement already concluded between the leaders of the victorious powers, which left the entire region administered as the
Soviet occupation zone The Soviet Occupation Zone ( or german: Ostzone, label=none, "East Zone"; , ''Sovetskaya okkupatsionnaya zona Germanii'', "Soviet Occupation Zone of Germany") was an area of Germany in Central Europe that was occupied by the Soviet Union as a c ...
(relaunched in October 1949 as the Soviet sponsored
German Democratic Republic German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Ger ...
). After the war ended the family were reunited in
Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...
, but while he was still at school they relocated to what came to be known as
East Berlin East Berlin was the ''de facto'' capital city of East Germany from 1949 to 1990. Formally, it was the Allied occupation zones in Germany, Soviet sector of Berlin, established in 1945. The American, British, and French sectors were known as ...
. His memoires recall that his parents were enthusiastic supporters of the new political structure in East Germany, although Oehme himself displayed outbursts of low-level rebelliousness, notably in the aftermath of the Hungarian uprising, when he was one of a group of medical student representatives demanding the abolition of compulsory lessons in the Russian language and Marxist-Leninist basic studies. Between 1955 and 1961 he studied
Medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...
at the
Humboldt University of Berlin Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative o ...
. It was here that he received his doctorate in 1962. Oehme launched his research career under the direction of Friedrich Jung at the (East) German Pharmacology Institute (''"Institut für Pharmakologie"'' / DAW) in
Buch (Berlin) Buch () is a German boroughs and localities of Berlin, locality (''Ortsteil'') within the Berlin borough (''Bezirk'') of Pankow. Situated on the Panke river, it is the city's northernmost quarter, chiefly known for its historic village centre an ...
. It was as a result of a conversation with Friedrich Jung that he toned down his expressions of political dissent, concentrating instead on his studies and research work. He switched, in 1967 to the Charité (university hospital), receiving his
habilitation Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including a ...
(higher academic qualification) for a piece of work on
Neuropharmacology Neuropharmacology is the study of how drugs affect function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmac ...
. As a result of his work he was in regular contact with academic colleagues in Prague, briefly visiting Czechoslovakia early in 1968 while accompanying students on an exchange visit. Impressed by the democratic stirrings in Czechoslovakia, on returning home he registered as a candidate for membership of East Germany's ruling Socialist Unity Party (''"Sozialistische Einheitspartei Deutschlands"'' / SED). He was deeply disappointed when Soviet tanks rolled into Prague in August of the same year, and by the ensuing "normalisation" process, but he nevertheless avoided any significant falling out with the authorities at home. In 1969 Oehme was appointed deputy director at the Research Centre for Molecular Biology and Medicine, the Association of Biosciences and Medical Support at the (East) German Academy of Sciences, where he had been a research assistant since 1967. During this period he was also teaching at the Humboldt. In 1970 he was appointed Professor for Experimental Pharmacology and a section head at the
Academy An academy ( Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy ...
. In 1974 he became deputy director at the Academy's National Institute for Molecular Biology. The
East German East Germany, officially the German Democratic Republic (GDR; german: Deutsche Demokratische Republik, , DDR, ), was a country that existed from its creation on 7 October 1949 until its dissolution on 3 October 1990. In these years the state ...
Drugs Reseatch Institute was launched at Oehme's instigation in 1976. It operated under the auspices of the (East) German Academy of Sciences, and between 1977 and 1991 Prof. Dr. Peter Oehme served as its first (and only) director. His objective with the institute was to make Berlin - initially East Berlin - a world centre for drugs research and by some criteria he succeeded in this. In 1992 the Institute re-emerged as the Leibniz Institute for Molecular Pharmacology (''"Leibniz-Institut für Molekulare Pharmakologie"''). In 2016 Oehme retained his connections with it, contributing his services as a research group leader and project group leader. He also took on teaching contracts at the
University of Potsdam The University of Potsdam is a public university in Potsdam, capital of the state of Brandenburg, Germany. It is mainly situated across three campuses in the city. Some faculty buildings are part of the New Palace of Sanssouci which is known ...
and at the Humboldt.


Work

One focus of Peter Oehme's research work has involved the origins of stress reactions, and their relationships with stress and
drug dependency Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has develope ...
. In particular, he has engaged with the operation of the
neuropeptide Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...
Substance P Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) and a member of the tachykinin neuropeptide family. It is a neuropeptide, acting as a neurotransmitter and as a neuromodulator. Substance P and its clos ...
in the
stress response The fight-or-flight or the fight-flight-or-freeze response (also called hyperarousal or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival. It was first des ...
and the body's adaptation.


Recognition and honours

* 1985 Corresponding member of the (East) German Academy of Sciences * 1988 External member of the Soviet Academy of Medical Sciences (since 1992 the Russian Academy of Medical Sciences) * 1988 Awarded
National Prize of the German Democratic Republic The National Prize of the German Democratic Republic (East Germany) (german: Nationalpreis der Deutschen Demokratischen Republik) was an award of the German Democratic Republic (GDR) given out in three different classes for scientific, artistic, ...
Class II (Sciences and technology) * 1990 Full member of the (East) German Academy of Sciences * 2014 External member of the
Russian Academy of Sciences The Russian Academy of Sciences (RAS; russian: Росси́йская акаде́мия нау́к (РАН) ''Rossíyskaya akadémiya naúk'') consists of the national academy of Russia; a network of scientific research institutes from across t ...


References

{{DEFAULTSORT:Oehme, Peter Physicians from Leipzig German pharmacologists 20th-century German physicians East German physicians Foreign Members of the Russian Academy of Sciences Recipients of the National Prize of East Germany 1937 births Living people Members of the German Academy of Sciences at Berlin East German scientists