Paul Lawrence Modrich (born June 13, 1946) is an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

James B. Duke Professor At Duke University, the title of James B. Duke Professor is given to a small number of the faculty with extraordinary records of achievement. At some universities, titles like "distinguished professor", "institute professor", or " regents professo ...

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

Duke University Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...

and Investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

. He is known for his research on

DNA mismatch repair DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of nucleobase, bases that can arise during DNA replication and Genetic recombination, recombination, as well as DNA repair, r ...

. Modrich received the

Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

2015, jointly with

Aziz Sancar Aziz Sancar (born 8September 1946) is a Turkish molecular biologist specializing in DNA repair, cell cycle checkpoints, and circadian clock. In 2015, he was awarded the Nobel Prize in Chemistry along with Tomas Lindahl and Paul L. Modrich for t ...

and

Tomas Lindahl Tomas Robert Lindahl FRS FMedSci (born 28 January 1938) is a Swedish-British scientist specialising in cancer research. In 2015, he was awarded the Nobel Prize in Chemistry jointly with American chemist Paul L. Modrich and Turkish chemist Aziz ...

Early life and education

Modrich was born on June 13, 1946, in

Raton, New Mexico Raton ( ) is a city and the county seat of Colfax County, New Mexico, Colfax County in northeastern New Mexico. The city is located just south of Raton Pass. The city is also located about 6.5 miles south of the New Mexico–Colorado border and 85 ...

to Laurence Modrich and Margaret McTurk. He has a younger brother Dave. His father was a biology teacher and coach for basketball, football and tennis at

Raton High School Raton High School (RHS) is a state school, public senior high school in Raton, New Mexico. It is a part of the Raton Public Schools district. History In 1891, the New Mexico Territorial Legislature approved taxes for the purpose of creating sta ...

where he graduated in 1964. Modrich is of Croatian, Montenegrin,

German German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Ger ...

and Scottish (Gaelic) origin. His paternal grandfather, of Croatian descent, is probably from the small village of Modrići near

Zadar Zadar ( , ; historically known as Zara (from Venetian and Italian: ); see also other names), is the oldest continuously inhabited Croatian city. It is situated on the Adriatic Sea, at the northwestern part of Ravni Kotari region. Zadar serv ...

, and grandmother of Montenegrin descent, both immigrated to the United States from coastal

Croatia , image_flag = Flag of Croatia.svg , image_coat = Coat of arms of Croatia.svg , anthem = "Lijepa naša domovino"("Our Beautiful Homeland") , image_map = , map_caption = , capit ...

in the late 19th century. His maternal family is of mixed German and Scotch-Irish descent. Modrich married fellow scientist Vickers Burdett in 1980. Modrich obtained a

B.S. A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University ...

degree from the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

in 1968 and subsequently a

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

degree from

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

in 1973. He continued his research as a postdoc in the lab of

Charles C. Richardson Charles Clifton Richardson (born May 7, 1935) is an American biochemist and professor at Harvard University. Richardson received his undergraduate education at Duke University, where he majored in medicine. He received his M.D. at Duke Medical ...

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

for a year (1973–1974).

Research

Modrich became an assistant professor at the chemistry department of

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

in 1974. He joined Duke University's faculty in 1976 and has been a Howard Hughes Investigator since 1995. He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase.

Matthew Meselson Matthew Stanley Meselson (born May 24, 1930) is a geneticist and molecular biologist currently at Harvard University, known for his demonstration, with Franklin Stahl, of semi-conservative DNA replication. After completing his Ph.D. under Linus ...

previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in ''E. coli''. They later searched for proteins associated with mismatch repair in humans.

Honors and awards

Honors and awards received by Modrich include: *1983:

Pfizer Award in Enzyme Chemistry The Pfizer Award in Enzyme Chemistry, formerly known as the Paul-Lewis Award in Enzyme Chemistry was established in 1945. Consisting of a gold medal and honorarium, its purpose is to stimulate fundamental research in enzyme chemistry by scientists ...

*1996: General Motors

Charles S. Mott Prize The Charles S. Mott Prize was awarded annually by the General Motors Cancer Research Foundation as one of a trio of scientific prizes entirely devoted to cancer research, the other two being the Charles F. Kettering Prize and the Alfred P. Sloan, J ...

in Cancer Research *1998:

Robert J. and Claire Pasarow Foundation Medical Research Award The Robert J. And Claire Pasarow Foundation Medical Research Awards were awarded annually for distinguished accomplishment in areas of investigation that included neuropsychiatry, cardiovascular disease, and cancer research. The program ran from 1 ...

for cancer research *2000 Feodor Lynen Medal *2005:

American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...

Medal of Honor *2015: Nobel Prize in Chemistry *2016: Arthur Kornberg and Paul Berg Lifetime Achievement Award in Biomedical Sciences Modrich is a fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

and a member of the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

and the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

References

External links

* {{DEFAULTSORT:Modrich, Paul L. 1946 births Nobel laureates in Chemistry Duke University faculty American people of Croatian descent American people of Montenegrin descent American people of German descent American people of Scotch-Irish descent Stanford University alumni American Nobel laureates American biochemists Howard Hughes Medical Investigators Living people Members of the United States National Academy of Sciences Fellows of the American Academy of Arts and Sciences People from Raton, New Mexico Articles containing video clips Members of the National Academy of Medicine