Pamoic acid, also called embonic acid, is a 2-Naphthoic acid derivative.

Salts In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively cha ...

and

ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ar ...

s of pamoic acid are known as pamoates or embonates. It can be prepared by the reaction of 3-hydroxy-2-naphthoic acid with

formaldehyde Formaldehyde ( , ) (systematic name methanal) is a naturally occurring organic compound with the formula and structure . The pure compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde (refer to section F ...

. In pharmacology, the salt form of pamoic acid (pamoate ion) can be used as a

counterion 160px, Polystyrene sulfonate, a cation-exchange resin, is typically supplied with as the counterion.">cation-exchange_resin.html" ;"title="Polystyrene sulfonate, a cation-exchange resin">Polystyrene sulfonate, a cation-exchange resin, is typical ...

of a drug compound to affect the dissolution rate of the drug. The presence of multiple oxygen atoms enables significant hydrogen bonding to occur. Hydrogen bonds facilitate the dissolution of compounds in water. Pharmaceutical drugs formulated this way include cycloguanil pamoate,

hydroxyzine pamoate Hydroxyzine, sold under the brand names Atarax, Vistaril and others, is an antihistamine medication. It is used in the treatment of itchiness, insomnia, anxiety, and nausea, including that due to motion sickness. It is used either by mouth or in ...

imipramine pamoate Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression (mood), depression. It is also effective in treating anxiety and panic disorder. The drug is also used to ...

, olanzapine pamoate hydrate,

oxantel pamoate Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms. Oxantel has been shown to inhibit fumarate reductase Fumarate reductase is the enzyme that converts fumarate to succinate, a ...

pyrantel pamoate Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. It is taken by mouth. Side effects inclu ...

, and pyrvinium pamoate. Pamoic acid has agonist activity for the

orphan An orphan (from the el, ορφανός, orphanós) is a child whose parents have died. In common usage, only a child who has lost both parents due to death is called an orphan. When referring to animals, only the mother's condition is usuall ...

G protein-coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

GPR35 G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the ''GPR35'' gene. Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberküh ...

by which it activates ERK and beta-arrestin2, and causes

antinociceptive Nociception (also nocioception, from Latin ''nocere'' 'to harm or hurt') is the Somatosensory system, sensory nervous system's process of encoding Noxious stimulus, noxious stimuli. It deals with a series of events and processes required for an org ...

activity.

References

{{reflist Dicarboxylic acids 2-Naphthols Naphthoic acids Alpha hydroxy acids Diols