Tissue kallikrein (, ''glandular kallikrein'', ''pancreatic kallikrein'', ''submandibular kallikrein'', ''submaxillary kallikrein'', ''kidney kallikrein'', ''urinary kallikrein'', ''
kallikrein
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by ''KLKB1 gene'') has no known paralogue, while tissue kallikrein-related peptidases (''KLKs'') encode a f ...
'', ''salivary kallikrein'', ''kininogenin'', ''kininogenase'', ''callicrein'', ''glumorin'', ''padreatin'', ''padutin'', ''kallidinogenase'', ''bradykininogenase'', ''depot-padutin'', ''urokallikrein'', ''dilminal D'', ''onokrein P'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: Preferential cleavage of Arg- bonds in small molecule substrates. It acts highly selectively to release
kallidin
Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins.
Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. It can be converted to bradykinin b ...
(lysyl-bradykinin) from
kininogen Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, inflammatory regulation, and the regulation of the cardiovascular and renal systems.
Types o ...
This enzyme is formed from tissue
prokallikrein by activation with
trypsin
Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting these long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the dig ...
.
See also
*
Kallikrein
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by ''KLKB1 gene'') has no known paralogue, while tissue kallikrein-related peptidases (''KLKs'') encode a f ...
References
External links
*
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EC 3.4.21