PANC-1 is a human
pancreatic cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancerous cells have the ability to invade other parts of the body. A number of types of panc ...
cell line
An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cel ...
isolated from a pancreatic carcinoma of
ductal cell origin.
PANC-1 was derived from the tissue of a 56-year-old male. The cells can
metastasize
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, ...
but have poor differentiation abilities.
PANC-1 cells take 52 hours to double in population, have a modal chromosome number of 63, and show G6PD of the slow mobility type.
PANC-1 cells are known to have an epithelial morphology and are adherent in
cell culture flasks. The cells can be frozen and regrown in culture, provided that they are appropriately warmed. Additionally, PANC-1 cells have a tendency to clump, a feature which can be avoided with
trypsinization
Trypsinization is the process of cell dissociation using trypsin, a proteolytic enzyme which breaks down proteins, to dissociate adherent cells from the vessel in which they are being cultured. When added to a cell culture, trypsin breaks down the ...
.
PANC-1 cells have been used to study the role of
keratin
Keratin () is one of a family of structural fibrous proteins also known as ''scleroproteins''. Alpha-keratin (α-keratin) is a type of keratin found in vertebrates. It is the key structural material making up scales, hair, nails, feathers, ...
reorganization during the migration of cancer cells, along with calcium-mediated actin reset in response to physiological changes.
See also
*
DU145
DU145 (DU-145) is a human prostate cancer
Prostate cancer is cancer of the prostate. Prostate cancer is the second most common cancerous tumor worldwide and is the fifth leading cause of cancer-related mortality among men. The prostate is a gla ...
*
BxPC-3 BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinoma
Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ) (AC) is a type of cancerous tumor that can occur in several parts of the body. It is ...
*
MIA PaCa-2
MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development.
In 1977, MIA PaCa-2 cells were derived from the carcinoma of a 65-year-old male.
The cells exhibit CK5.6, AE1/AE3, E-cad ...
References
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External links
Cellosaurus entry for PANC-1
Human cell lines