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''Orthohepadnavirus'' is a genus of
virus A virus is a wikt:submicroscopic, submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and ...
es, in the family '' Hepadnaviridae''. Humans and other mammals serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include:
hepatitis Hepatitis is inflammation of the liver parenchyma, liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), Anorexia (symptom), poor appetite ...
, hepatocellular carcinoma (chronic infections), and
cirrhosis Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the impaired liver function caused by the formation of scar tissue known as fibrosis due to damage caused by liver disease. Damage causes tissue repai ...
.


Taxonomy

The genus contains the following species: * '' Capuchin monkey hepatitis B virus'' * '' Chinese shrew hepatitis B virus'' * '' Domestic cat hepatitis B virus'' * '' Ground squirrel hepatitis virus'' * '' Hepatitis B virus'' * '' Long-fingered bat hepatitis B virus'' * '' Pomona bat hepatitis B virus'' * '' Roundleaf bat hepatitis B virus'' * '' Taï Forest hepadnavirus'' * '' Tent-making bat hepatitis B virus'' * '' Woodchuck hepatitis virus'' * '' Woolly monkey hepatitis B virus''


Structure

Viruses in the genus ''Orthohepadnavirus'' are enveloped, with spherical geometries, and T=4 symmetry. The diameter is around 42 nm. Genomes are circular, around 3.2kb in length. The genome codes for 7 proteins.


Life cycle

Viral replication is nucleo-cytoplasmic. Replication follows the dsDNA(RT) replication model. DNA-templated transcription, specifically dsDNA(RT) transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by budding, and nuclear pore export. Human and mammals serve as the natural host. Transmission routes are sexual, blood, and contact.


References


External links


ICTV Report: ''Hepadnaviridae''


{{Taxonbar, from=Q6746239 Hepadnaviridae Virus genera