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Woodchuck Hepatitis Virus
''Woodchuck hepatitis virus'' (WHV) is a species of the genus ''Orthohepadnavirus''. It was first discovered in 1977 in a captive population of '' Marmota monax'', but has since been discovered in wild populations in the Eastern United States. Infected woodchucks which are unable to clear the infection inevitably develop hepatocellular carcinoma; this has led to the use of WHV in woodchucks as a model for human ''Hepatitis B virus ''Hepatitis B virus'' (HBV) is a partially double-stranded DNA virus, a species of the genus ''Orthohepadnavirus'' and a member of the ''Hepadnaviridae'' family of viruses. This virus causes the disease hepatitis B. Disease Despite there bein ...'' infections. References Animal viral diseases Hepadnaviridae Groundhogs {{Virus-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthohepadnavirus
''Orthohepadnavirus'' is a genus of viruses, in the family ''Hepadnaviridae''. Humans and other mammals serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include: hepatitis, hepatocellular carcinoma (chronic infections), and cirrhosis. Taxonomy The genus contains the following species: * '' Capuchin monkey hepatitis B virus'' * ''Chinese shrew hepatitis B virus'' * ''Domestic cat hepatitis B virus'' * ''Ground squirrel hepatitis virus'' * ''Hepatitis B virus'' * '' Long-fingered bat hepatitis B virus'' * ''Pomona bat hepatitis B virus'' * '' Roundleaf bat hepatitis B virus'' * ''Taï Forest hepadnavirus'' * '' Tent-making bat hepatitis B virus'' * ''Woodchuck hepatitis virus'' * ''Woolly monkey hepatitis B virus The ''woolly monkey hepatitis B virus'' (WMHBV) is a viral species of the ''Orthohepadnavirus'' genus of the ''Hepadnaviridae'' family. Its natural host is the woolly monkey (''Lagothrix)'', an inhabitant of South America c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marmota Monax
The groundhog (''Marmota monax''), also known as a woodchuck, is a rodent of the family Sciuridae, belonging to the group of large ground squirrels known as marmots. The groundhog is a lowland creature of North America; it is found through much of the Eastern United States, across Canada and into Alaska. It was first scientifically described by Carl Linnaeus in 1758. The groundhog is also referred to as a chuck, wood-shock, groundpig, whistlepig, whistler, thickwood badger, Canada marmot, monax, moonack, weenusk, red monk, land beaver, and, among French Canadians in eastern Canada, siffleux. The name "thickwood badger" was given in the Northwest to distinguish the animal from the prairie badger. Monax (''Móonack'') is an Algonquian name of the woodchuck, which means "digger" (cf. Lenape ''monachgeu''). Young groundhogs may be called chucklings. The groundhog, being a lowland animal, is exceptional among marmots. Other marmots, such as the yellow-bellied and hoary marmots ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eastern United States
The Eastern United States, commonly referred to as the American East, Eastern America, or simply the East, is the region of the United States to the east of the Mississippi River. In some cases the term may refer to a smaller area or the East Coast plus Illinois, Wisconsin, Indiana, Mississippi, and their border states. In 2011, the 26 states east of the Mississippi (in addition to Washington, D.C. but not including the small portions of Louisiana and Minnesota east of the river) had an estimated population of 179,948,346 or 58.28% of the total U.S. population of 331,745,358 (excluding Puerto Rico). New England New England is a region of the United States located in the northeastern corner of the country, bounded by the Atlantic Ocean, Canada and the state of New York, consisting of the modern states of Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, and Connecticut. In one of the earliest English settlements in the New World, English Pilgrims from Europe first ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. HCC is the third leading cause of cancer-related deaths worldwide. It occurs in the setting of chronic liver inflammation, and is most closely linked to chronic viral hepatitis infection (hepatitis B or C) or exposure to toxins such as alcohol, aflatoxin, or pyrrolizidine alkaloids. Certain diseases, such as hemochromatosis and alpha 1-antitrypsin deficiency, markedly increase the risk of developing HCC. Metabolic syndrome and NASH are also increasingly recognized as risk factors for HCC. As with any cancer, the treatment and prognosis of HCC vary depending on the specifics of tumor histology, size, how far the cancer has spread, and overall health. The vast majority of HCC cases and the lowest survival rates after treatment occur in Asia and sub-Saharan Africa, in countries where hepatitis B infection is endem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatitis B Virus
''Hepatitis B virus'' (HBV) is a partially double-stranded DNA virus, a species of the genus ''Orthohepadnavirus'' and a member of the ''Hepadnaviridae'' family of viruses. This virus causes the disease hepatitis B. Disease Despite there being a vaccine to prevent Hepatitis B, HBV remains a global health problem. Hepatitis B can be acute and later become chronic, leading to other diseases and health conditions. In addition to causing hepatitis, infection with HBV can lead to cirrhosis and hepatocellular carcinoma. It has also been suggested that it may increase the risk of pancreatic cancer. Roles in disease Viral infection by ''Hepatitis B virus'' (HBV) causes many hepatocyte changes due to the direct action of a protein encoded by the virus, HBx, and to indirect changes due to a large increase in intracellular reactive oxygen species (ROS) after infection. HBx appears to dysregulate a number of cellular pathways. HBx causes dysregulation in part by binding to genomic DNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Viral Diseases
Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia. With few exceptions, animals consume organic material, breathe oxygen, are able to move, can reproduce sexually, and go through an ontogenetic stage in which their body consists of a hollow sphere of cells, the blastula, during embryonic development. Over 1.5 million living animal species have been described—of which around 1 million are insects—but it has been estimated there are over 7 million animal species in total. Animals range in length from to . They have complex interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology. Most living animal species are in Bilateria, a clade whose members have a bilaterally symmetric body plan. The Bilateria include the protostomes, containing animals such as nematodes, arthropods, flatworms, annelids and molluscs, and the deuterostomes, containing the echinoderms an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepadnaviridae
''Hepadnaviridae'' is a family of viruses. Humans, apes, and birds serve as natural hosts. There are currently 18 species in this family, divided among 5 genera. Its best-known member is hepatitis B virus. Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic infections), and cirrhosis. It is the sole accepted family in the order ''Blubervirales''. Taxonomy The following genera are recognized: * ''Avihepadnavirus'' * ''Orthohepadnavirus'' * '' Herpetohepadnavirus'' * '' Metahepadnavirus'' * '' Parahepadnavirus'' History and discovery Although liver diseases transmissible among human populations were identified early in the history of medicine, the first known hepatitis with a viral etiological agent was Hepatitis A, in the picornaviridae family. Hepatitis B Virus (HBV) was identified as an infection distinct from Hepatitis A through its contamination of measles, mumps, and yellow fever vaccines in the 1930s and 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
