Ophidian may refer to:
*Ophidian, a reptile of the suborder ''
Ophidia
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Ophidia (also known as Pan-Serpentes) is a group of squamate reptiles including modern snakes and reptiles more closely related to snakes than to other living groups of lizards.
Ophidia was defined as the "most recent common ancest ...
'' (or '' Serpentes''); a snake
*
Ophidian (wrestler)
Ophidian is a retired professional wrestler best known for performing with Chikara. He was previously a member of The Osirian Portal stable along with his former partners Amasis and Hieracon. His gimmick is an anthropomorphic Egyptian cobra, whic ...
, a professional wrestler
*
Ophidian (Dungeons & Dragons), a Dungeons & Dragons monster
*
Ophidian 2350, a collectible card game
*Ophidian, a fictional hotel from the American TV show ''
Supernatural''
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