OPH may refer to:
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Aryldialkylphosphatase, an enzyme
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Ophiuchus
Ophiuchus () is a large constellation straddling the celestial equator. Its name comes from the Ancient Greek (), meaning "serpent-bearer", and it is commonly represented as a man grasping a snake. The serpent is represented by the constella ...
, a constellation
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Original Pancake House, an American restaurant chain
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