''O''-Acetylbufotenine (5-AcO-DMT, bufotenine acetate) is a
tryptamine derivative which produces
psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
-appropriate responding in animal studies. It is an acylated derivative of
bufotenine with higher
lipophilicity that allows it to cross the
blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane, semipermeable border of endothelium, endothelial cells that prevents solutes in the circulating blood from ''non-selectively'' crossing into the extracellular fluid of ...
; once inside the brain, it is metabolised to bufotenine.
It also acts directly as an agonist at 5-HT
1A and 5-HT
1D receptors.
See also
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4-AcO-DMT
''O''-Acetylpsilocin (also known as psilacetin, 4-acetoxy-DMT, 4-AcO-DMT, or synthetic shrooms) is a semi-synthetic psychoactive drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacolog ...
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5-EtO-DMT
5-Ethoxy-DMT (5-ethoxy-''N'',''N''-dimethyltryptamine, 5-EtO-DMT, ''O''-ethylbufotenine) is a tryptamine derivative which has been previously synthesized as a chemical intermediate, but has not been studied to determine its pharmacology.
The wid ...
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5-HO-AMT
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5-HO-DiPT
5-HO-DiPT (5-hydroxy-''N,N''-di-''iso''-propyltryptamine) is a tryptamine derivative which acts as a serotonin receptor agonist. It is primarily known as a metabolite of the better known psychoactive drug 5-MeO-DiPT, but 5-HO-DiPT has also rarely ...
References
Designer drugs
Psychedelic tryptamines
Serotonin receptor agonists
Tertiary amines
Acetate esters
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