Kinetochore protein NDC80 homolog is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''NDC80''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

Ndc80 is one of the proteins of outer

kinetochore A kinetochore (, ) is a disc-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore assembles on the centromere and ...

. It forms a

heterotetramer A tetrameric protein is a protein with a quaternary structure of four subunits (tetrameric). Homotetramers have four identical subunits (such as glutathione S-transferase), and heterotetramers are complexes of different subunits. A tetramer ca ...

with proteins

NUF2 Kinetochore protein Nuf2 is a protein that in humans is encoded by the ''NUF2'' gene. This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappea ...

SPC25 SPC may refer to: Business and law * Segregated portfolio company, Segregated Portfolio Company, a specialized form of offshore company * Signature panel code, a credit or debit card security code * Social purpose corporation, Social Purpose Corpo ...

, and SPC24. This protein complex has

microtubule Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 an ...

-binding domains. HEC is one of several

s involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.

Interactions

NDC80 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

MIS12 Protein MIS12 homolog is a protein that in humans is encoded by the ''MIS12'' gene. Interactions MIS12 has been shown to interact with NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1 DSN1, MIND kinetochore complex component, ho ...

NEK2 Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the ''NEK2'' gene. Interactions NEK2 has been shown to interact with MAPK1 and NDC80 Kinetochore protein NDC80 homolog is a protein that in humans is encoded by th ...

and

PSMC2 26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the ''PSMC2'' gene This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. ...

Function

Interactions

References

Further reading