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MIS12
Protein MIS12 homolog is a protein that in humans is encoded by the ''MIS12'' gene. Interactions MIS12 has been shown to interact with NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the ''DSN1'' gene. Function DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore- ... and CBX5. References Further reading * * * * * * * * * {{Gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CASC5
KNL1 (kinetochore scaffold 1, aka CASC5) is a protein that is encoded by the ''KNL1'' gene in humans. Function KNL1 is part of the outer kinetochore. It is a part of KMN network of proteins together with MIS12, and NDC80. KNL1 is involved in microtubule attachment to chromosome centromeres and in the activation of the spindle checkpoint during mitosis. The ''CASC5'' gene is upregulated in the areas of cell proliferation surrounding the ventricles during fetal brain development. Interactions CASC5 has been shown to interact with MIS12, BUB1, BUBR1 and ZWINT-1. Polymorphisms Homozygous polymorphisms in the ''CASC5'' gene have been seen in patients with autosomal recessive primary microcephaly (MCPH). The mutation resulted in the skipping of exon 18 transcription, causing a frameshift Ribosomal frameshifting, also known as translational frameshifting or translational recoding, is a biological phenomenon that occurs during translation that results in the production of multip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DSN1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the ''DSN1'' gene. Function DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis. Interactions DSN1 has been shown to interact with NSL1 and MIS12 Protein MIS12 homolog is a protein that in humans is encoded by the ''MIS12'' gene. Interactions MIS12 has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex Youth, is .... References Further reading * * * * * * * * * {{gene-20-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NSL1
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the ''NSL1'' gene. This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. Interactions NSL1 has been shown to interact with MIS12 and DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the ''DSN1'' gene. Function DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZWINT
ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ''ZWINT'' gene. Function Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Interactions ZWINT has been shown to interact with MIS12. ZWINT has also been shown to interact with RAB3C Ras-related protein Rab-3C is a protein that in humans is encoded by the ''RAB3C'' gene. Interactions Rab3C has been shown to interact with ZWINT ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ''ZWINT'' gene. Funct ... References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyamine-modulated Factor 1
Polyamine-modulated factor 1 is a protein that in humans is encoded by the ''PMF1'' gene. Interactions Polyamine-modulated factor 1 has been shown to interact with MIS12 Protein MIS12 homolog is a protein that in humans is encoded by the ''MIS12'' gene. Interactions MIS12 has been shown to interact with NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1 DSN1, MIND kinetochore complex component, ho .... References Further reading * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NDC80
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the ''NDC80'' gene. Function Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved. Interactions NDC80 has been shown to interact with MIS12, NEK2 and PSMC2 26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the ''PSMC2'' gene This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. .... References Further reading * * * * * * * * * * * * * * * * {{PD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
