DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

which in humans encoded by the ''DSN1''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

DSN1 along with

MIS12 Protein MIS12 homolog is a protein that in humans is encoded by the ''MIS12'' gene. Interactions MIS12 has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex Youth, is ...

, DC8,

PMF1 Polyamine-modulated factor 1 is a protein that in humans is encoded by the ''PMF1'' gene. Interactions Polyamine-modulated factor 1 has been shown to interact with MIS12 Protein MIS12 homolog is a protein that in humans is encoded by the ''M ...

, CBX5,

ZWINT ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ''ZWINT'' gene. Function Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, pos ...

is a component of the

kinetochore A kinetochore (, ) is a disc-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore assembles on the centromere and ...

-associated multiprotein complex which is required for correct chromosome alignment during the

metaphase Metaphase ( and ) is a stage of mitosis in the eukaryotic cell cycle in which chromosomes are at their second-most condensed and coiled stage (they are at their most condensed in anaphase). These chromosomes, carrying genetic information, alig ...

of cell

mitosis In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is mainta ...

Interactions

DSN1 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

NSL1 Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the ''NSL1'' gene. This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that atta ...

and

Function

Interactions

References

Further reading