Nikolay Fyodorovich Gamaleya (russian: Никола́й Фёдорович Гамале́я; – 29 March 1949) was a
Russian
Russian(s) refers to anything related to Russia, including:
*Russians (, ''russkiye''), an ethnic group of the East Slavic peoples, primarily living in Russia and neighboring countries
*Rossiyane (), Russian language term for all citizens and peo ...
and
Soviet
The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a List of former transcontinental countries#Since 1700, transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, ...
physician
A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
and
scientist
A scientist is a person who conducts Scientific method, scientific research to advance knowledge in an Branches of science, area of the natural sciences.
In classical antiquity, there was no real ancient analog of a modern scientist. Instead, ...
who played a pioneering role in
microbiology
Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, prot ...
and
vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifie ...
research.
Biography
Gamaleya was born in
Odessa
Odesa (also spelled Odessa) is the third most populous city and municipality in Ukraine and a major seaport and transport hub located in the south-west of the country, on the northwestern shore of the Black Sea. The city is also the administrativ ...
, then part of the
Russian Empire
The Russian Empire was an empire and the final period of the Russian monarchy from 1721 to 1917, ruling across large parts of Eurasia. It succeeded the Tsardom of Russia following the Treaty of Nystad, which ended the Great Northern War. ...
. He graduated from Odessa's Novorossiysky University (now
Odessa University
Odesa I. I. Mechnykov National University ( uk, Одеський національний університет Iмені І. І. Мечникова, translit=Odeskyi natsionalnyi universytet imeni I. I. Mechnykova), located in Odesa, Ukraine, i ...
) in 1880 and the St. Petersburg Military Medical Academy (now the
S.M. Kirov Military Medical Academy
The S. M. Kirov Military Medical Academy (russian: Военно-медицинская академия имени С. М. Кирова) is a higher education institution of military medicine in Saint Petersburg and the Russian Federation. Senio ...
) in 1883. He became a respected hospital physician in his native Odessa afterward.
Gamaleya worked in
Louis Pasteur
Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named afte ...
's laboratory in
France
France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...
in 1886. Following Pasteur's model after his return, he joined
Ilya Mechnikov
Ilya, Iliya, Ilia, Ilja, or Ilija (russian: Илья́, Il'ja, , or russian: Илия́, Ilija, ; uk, Ілля́, Illia, ; be, Ілья́, Iĺja ) is the East Slavic form of the male Hebrew name Eliyahu (Eliahu), meaning "My God is Yahu/ Jah. ...
in organizing an Odessa bacteriological station for
rabies
Rabies is a viral disease that causes encephalitis in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: nausea, vomiting, vi ...
vaccination
Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating ...
studies and research on combating
cattle plague
Rinderpest (also cattle plague or steppe murrain) was an infectious viral disease of cattle, domestic buffalo, and many other species of even-toed ungulates, including gaurs, buffaloes, large antelope, deer, giraffes, wildebeests, and warthogs ...
and
cholera
Cholera is an infection of the small intestine by some strains of the bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and ...
, diagnosing
sputum
Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked eye examination, microbiological investigation of respiratory infections and cytological investigations ...
for
tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in ...
, and preparing
anthrax
Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...
vaccines.
[Zalkind, Semyon (2001). ''Ilya Mechnikov: His Life and Work''. Honolulu, Hawaii: University Press of the Pacific. pp. 96-98. .] The Odessa Bacteriological Institute became Russia's first-ever bacteriological observation station.
Despite the poor facilities and the small staff, the scientists were able to succeed in figuring out the conditions under which the rabies vaccination was most effective.
Gamaleya's proposal for using killed
bacilli
Bacilli is a taxonomic class of bacteria that includes two orders, Bacillales and Lactobacillales, which contain several well-known pathogens such as ''Bacillus anthracis'' (the cause of anthrax). ''Bacilli'' are almost exclusively gram-positive ...
in anti-cholera vaccines was later successfully applied on a wide scale as well.
Similar stations were soon founded in
Kiev
Kyiv, also spelled Kiev, is the capital and most populous city of Ukraine. It is in north-central Ukraine along the Dnieper, Dnieper River. As of 1 January 2021, its population was 2,962,180, making Kyiv the List of European cities by populat ...
(1886),
Yekaterinoslav
Dnipro, previously called Dnipropetrovsk from 1926 until May 2016, is Ukraine's fourth-largest city, with about one million inhabitants. It is located in the eastern part of Ukraine, southeast of the Ukrainian capital Kyiv on the Dnieper Rive ...
(1897), and
Chernigov
Chernihiv ( uk, Черні́гів, , russian: Черни́гов, ; pl, Czernihów, ; la, Czernihovia), is a List of cities in Ukraine, city and List of hromadas of Ukraine, municipality in northern Ukraine, which serves as the administrative ...
(1897).
After defending his 1892 dissertation on the
etiology
Etiology (pronounced ; alternatively: aetiology or ætiology) is the study of causation or origination. The word is derived from the Greek (''aitiología'') "giving a reason for" (, ''aitía'', "cause"); and ('' -logía''). More completely, e ...
of cholera (published in 1893), Gamaleya served as director of the Odessa Bacteriological Institute in 1896-1908. Reporting of the
lysis
Lysis ( ) is the breaking down of the membrane of a cell, often by viral, enzymic, or osmotic (that is, "lytic" ) mechanisms that compromise its integrity. A fluid containing the contents of lysed cells is called a ''lysate''. In molecular bio ...
of ''
Bacillus anthracis
''Bacillus anthracis'' is a gram-positive and rod-shaped bacterium that causes anthrax, a deadly disease to livestock and, occasionally, to humans. It is the only permanent ( obligate) pathogen within the genus ''Bacillus''. Its infection is a ...
'' bacteria by a transmissible "ferment" in 1898, Gamaleya was the discoverer of the bacteria-destroying
antibodies
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
known as
bacteriolysins.
[Melikishvili, Alexander (2008)]
"Annex: Biosketches of Scientists and Other Public Figures Who Played Important Roles in the Evolution of Tsarist Russia’s Anti-Plague System".
In Sonia Ben Ouagrham-Gormley, Alexander Melikishvili, and Raymond A. Zilinskas
The Soviet Anti-Plague System
James Martin Center for Nonproliferation Studies
The Middlebury Institute of International Studies at Monterey (MIIS), formerly known as the Monterey Institute of International Studies, is an American graduate school of Middlebury College, a private college in Middlebury, Vermont.
Established ...
. Retrieved 26 February 2011.
Gamaleya initiated a public health campaign of exterminating rats to fight the
plague
Plague or The Plague may refer to:
Agriculture, fauna, and medicine
*Plague (disease), a disease caused by ''Yersinia pestis''
* An epidemic of infectious disease (medical or agricultural)
* A pandemic caused by such a disease
* A swarm of pes ...
in Odessa and southern Russia and pointed to the
louse
Louse ( : lice) is the common name for any member of the clade Phthiraptera, which contains nearly 5,000 species of wingless parasitic insects. Phthiraptera has variously been recognized as an order, infraorder, or a parvorder, as a result o ...
as the carrier of
typhus
Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure.
...
.
[Podolsky, Edward (1972). ''Red Miracle: The Story of Soviet Medicine''. New York: Beechhurst Press. p. 222. .] In 1910-1913, Gamaleya edited the journal ''Gigiena i sanitariya'' (''Hygiene and Sanitation'').
Gamaleya's later work, including organizing the supply and distribution of
smallpox
Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...
vaccines for the
Red Army
The Workers' and Peasants' Red Army (Russian: Рабо́че-крестья́нская Кра́сная армия),) often shortened to the Red Army, was the army and air force of the Russian Soviet Federative Socialist Republic and, after ...
, made strides toward the
eventual eradication of smallpox in the USSR.
[Podolsky, Edward (1972). ''Red Miracle: The Story of Soviet Medicine''. New York: Beechhurst Press. p. 224. .]
The author of more than 300 academic publications on bacteriology, Gamaleya was a member of the
Academy of Sciences of the USSR
The Academy of Sciences of the Soviet Union was the highest scientific institution of the Soviet Union from 1925 to 1991, uniting the country's leading scientists, subordinated directly to the Council of Ministers of the Soviet Union (until 1946 ...
and the
USSR Academy of Medical Sciences The USSR Academy of Medical Sciences (russian: Акаде́мия медици́нских нау́к СССР) was the highest scientific and medical organization founded in the Soviet Union founded in 1944.
Its successor is the Russian Academy of ...
. He also served as head of the All-Union Society of Microbiologists, Epidemiologists and Infectionists.
The highly regarded Gamaleya's state honors included two
Lenin Orders, the
Order of the Red Banner of Labour
The Order of the Red Banner of Labour (russian: Орден Трудового Красного Знамени, translit=Orden Trudovogo Krasnogo Znameni) was an order of the Soviet Union established to honour great deeds and services to th ...
, and the 1943
State Stalin Prize
The USSR State Prize (russian: links=no, Государственная премия СССР, Gosudarstvennaya premiya SSSR) was the Soviet Union's state honor. It was established on 9 September 1966. After the dissolution of the Soviet Union, t ...
.
Gamaleya died in
Moscow
Moscow ( , US chiefly ; rus, links=no, Москва, r=Moskva, p=mɐskˈva, a=Москва.ogg) is the capital and largest city of Russia. The city stands on the Moskva River in Central Russia, with a population estimated at 13.0 million ...
.
The
N. F. Gamaleya Federal Research Center for Epidemiology & Microbiology in Moscow is named after him.
References
Further reading
*
External links
1859 births
1949 deaths
Burials at Novodevichy Cemetery
Honorary Members of the USSR Academy of Sciences
Academicians of the USSR Academy of Medical Sciences
Physicians from Odesa
Stalin Prize winners
Recipients of the Order of Lenin
Recipients of the Order of the Red Banner of Labour
Russian bacteriologists
Russian microbiologists
Russian medical researchers
Soviet bacteriologists
Soviet microbiologists
Ukrainian bacteriologists
Ukrainian microbiologists
Odesa University alumni
S.M. Kirov Military Medical Academy alumni
{{Gamaleya Research Institute of Epidemiology and Microbiology