In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a N-formylmethionylaminoacyl-tRNA deformylase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:N-formyl-L-methionylaminoacyl-tRNA + H
2O
formate + L-methionylaminoacyl-tRNA
Thus, the two
substrates of this enzyme are
N-formyl-L-methionylaminoacyl-tRNA and
H2O, whereas its two
products are
formate
Formate (IUPAC name: methanoate) is the conjugate base of formic acid. Formate is an anion () or its derivatives such as ester of formic acid. The salts and esters are generally colorless.Werner Reutemann and Heinz Kieczka "Formic Acid" in ''Ull ...
and
L-methionylaminoacyl-tRNA.
This enzyme belongs to the family of
hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The
systematic name of this enzyme class is N-formyl-L-methionylaminoacyl-tRNA amidohydrolase. This enzyme participates in
glyoxylate and dicarboxylate metabolism Glyoxylate and dicarboxylate metabolism describes a variety of reactions involving glyoxylate or dicarboxylates. Glyoxylate is the conjugate base of glyoxylic acid, and within a buffered environment of known pH such as the cell cytoplasm these ter ...
.
Structural studies
As of late 2007, 3
structures have been solved for this class of enzymes, with
PDB accession codes , , and .
References
*
EC 3.5.1
Enzymes of known structure
{{3.5-enzyme-stub