''N''-Oxalylglycine is the
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon- hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. Th ...
with the
formula HO
2CC(O)NHCH
2CO
2H. This colourless solid is used as an inhibitor of α-ketoglutarate-dependent enzymes.
[Hausinger, R. P."Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes" Critical Reviews of Biochemical Molecular Biology 2004, 39: pp 21-68. ] It is isosteric with
α-ketoglutaric acid. Such enzymes are pervasive and, for example, are required for the synthesis of
4-hydroxyproline
(2''S'',4''R'')-4-Hydroxyproline, or L-hydroxyproline ( C5 H9 O3 N), is an amino acid, abbreviated as Hyp or O, ''e.g.'', in Protein Data Bank.
Structure and discovery
In 1902, Hermann Emil Fischer isolated hydroxyproline from hydrolyzed gelatin. ...
.
References
{{DEFAULTSORT:Oxalylglycine, N-
Carboxamides
Dicarboxylic acids