Mavacoxib (trade name Trocoxil) is a

veterinary drug An animal drug (also veterinary drug) refers to a pharmaceutical drug, drug intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in animals. Regulation United States The U.S. Food and Drug Administration (FDA) ...

used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a

COX-2 inhibitor COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration and i ...

. Mavacoxib, along with other COX-2 selective inhibitors,

celecoxib Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankyl ...

valdecoxib Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. It was patented in 1995. V ...

, and

parecoxib Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved through much of Europe for short term perioperative p ...

, were discovered by a team at the

Searle Searle may refer to: __NOTOC__ Persons * Searle (surname) * J. Searle Dawley (1877–1949), American film director, producer, screenwriter, stage actor and playwright * Searle Turton (born 1979), Canadian politician Places * Serle, a comune in Lomb ...

division of

Monsanto The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup, a glyphosate-based herbicide, developed in th ...

led by John Talley.

References

COX-2 inhibitors Nonsteroidal anti-inflammatory drugs Fluoroarenes Sulfonamides Pyrazoles Trifluoromethyl compounds {{musculoskeletal-drug-stub