''Carnivore bocaparvovirus 1'', formerly ''Canine minute virus'' (or minute virus of canines; MVC) is a species of ''

Bocaparvovirus ''Bocaparvovirus'' is a genus of viruses in the subfamily ''Parvovirinae'' of the virus family ''Parvoviridae''. Humans, cattle, and dogs serve as natural hosts. There are 28 species in this genus. Diseases associated with this genus include, in ...

'' of the family ''

Parvoviridae Parvoviruses are a family of animal viruses that constitute the family ''Parvoviridae''. They have linear, single-stranded DNA (ssDNA) genomes that typically contain two genes encoding for a replication initiator protein, called NS1, and the pr ...

'' that infects

dog The dog (''Canis familiaris'' or ''Canis lupus familiaris'') is a domesticated descendant of the wolf. Also called the domestic dog, it is derived from the extinct Pleistocene wolf, and the modern wolf is the dog's nearest living relative. Do ...

s. It is similar to '' bovine parvovirus'' in its

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

structure and DNA. A virus causing respiratory disease in humans has been called ''

human bocavirus Human bocavirus (HBoV) is the name given to all viruses in the genus ''Bocaparvovirus'' of virus family ''Parvoviridae'' that are known to infect humans. HBoV1 and HBoV3 (and gorilla bocaparvovirus) are members of species '' Primate bocaparvovir ...

'' due to its similarity to these viruses. Canine minute virus was originally discovered in Germany in 1967 in military dogs, although it was originally thought to not cause disease. Dogs and puppies are infected orally, and the virus is spread transplacentally to the fetuses. Symptoms are seen most commonly between the ages of one to three weeks and include severe

diarrhea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wi ...

, difficulty breathing, and

anorexia Anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low weight, food restriction, body image disturbance, fear of gaining weight, and an overpowering desire to be thin. ''Anorexia'' is a term of Gre ...

. In severe cases, illness can be fatal. In experimental infections, the virus is spread transplacentally when the

dam A dam is a barrier that stops or restricts the flow of surface water or underground streams. Reservoirs created by dams not only suppress floods but also provide water for activities such as irrigation, human consumption, industrial use, a ...

is infected between 25 and 30 days of gestation and can result in abortion. When the dam is infected between 30 and 35 days, the puppies were sometimes born with

myocarditis Myocarditis, also known as inflammatory cardiomyopathy, is an acquired cardiomyopathy due to inflammation of the heart muscle. Symptoms can include shortness of breath, chest pain, decreased ability to exercise, and an irregular heartbeat. The ...

and

anasarca Anasarca is a severe and generalized form of edema, with subcutaneous tissue swelling throughout the body. Unlike typical edema, which almost everyone will experience at some time and can be relatively benign, anasarca is a pathological process ...

Pathological Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...

lesions in fetuses in experimental infections were found in the

lung The lungs are the primary organs of the respiratory system in humans and most other animals, including some snails and a small number of fish. In mammals and most other vertebrates, two lungs are located near the backbone on either side of t ...

and

small intestine The small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the p ...

Virology

The genome is 5.4 kilobases in length. The termini are palindromic. There is a single P6 promoter which through the mechanism of alternative splicing and alternative polyadenylation two nonstructural proteins (NS1 and NP1) and two capsid proteins (VP1 and VP2) are transcribed. The NS1 protein is indispensable for genome replication. The NP1 protein, unique to the Bocaparvovirus genus, appears to be critical for optimal viral replication, as the NP1 knockout mutant of MVC suffers from severe impairment of replication.

References

{{Taxonbar, from=Q18907848, from2=Q5032416 Animal viral diseases Dog diseases Parvovirinae