Michael Samuel Neuberger FRS FMedSci (2 November 1953 – 26 October 2013) was a British biochemist and immunologist.

Biography

Born in

Kensington Kensington is a district in the Royal Borough of Kensington and Chelsea in the West End of London, West of Central London. The district's commercial heart is Kensington High Street, running on an east–west axis. The north-east is taken up b ...

, Michael Samuel Neuberger was the fourth of five children of Albert Neuberger and Lilian Ida (née Dreyfus). He was educated at

Westminster School (God Gives the Increase) , established = Earliest records date from the 14th century, refounded in 1560 , type = Public school Independent day and boarding school , religion = Church of England , head_label = Hea ...

and

Trinity College, Cambridge Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by Henry VIII, King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge ...

, from where he graduated with a first class honours degree in Natural Sciences in 1974. Neuberger then joined Brian Hartley at Imperial College to study for his PhD. During this time, and at Hartley’s suggestion, he visited the South African biologist

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work ...

at the

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

(LMB) in Cambridge. Their discussions drew Neuberger back to the LMB in 1980 and he remained there for the rest of his career, eventually becoming its deputy director.

César Milstein César Milstein, CH, FRS (8 October 1927 – 24 March 2002) was an Argentine biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler for d ...

at the LMB recommended that Neuberger spent some time studying immunology with

Klaus Rajewsky Klaus Rajewsky (born 12 November 1936 in Frankfurt am Main) is a German immunologist, renowned for his work on B cells. He studied medicine in Frankfurt, Munich and at the Pasteur Institute, Paris. In 1964 he started working at the Institute ...

at the

University of Cologne The University of Cologne (german: Universität zu Köln) is a university in Cologne, Germany. It was established in the year 1388 and is one of the most prestigious and research intensive universities in Germany. It was the sixth university to ...

; he spent 18 months there, after his PhD. Neuberger “was probably most widely known for delineating the role of DNA deamination in immunity through his pioneering work that explained how cytosine deamination drives the somatic hypermutation and class-switch recombination of antibody-encoding genes. Following the identification of activation-induced cytidine deaminase (AID) by Honjo and Durandy as the protein essential for both of those processes, Michael produced a series of seminal papers during 2002 that laid bare the mechanism that had perplexed immunologists for 30 years.”

Family

Michael Neuberger married Gillian Anne (Gill) Pyman, an Australian doctor, on 6 September 1991. They had four children: Saskia, Lydia, Thomas and Benjamin. He died of myeloma, a cancer of antibody-producing cells, at

Addenbrooke's Hospital Addenbrooke's Hospital is an internationally renowned large teaching hospital and research centre in Cambridge, England, with strong affiliations to the University of Cambridge. Addenbrooke's Hospital is based on the Cambridge Biomedical Campu ...

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

, on 26 October 2013. "At his request, he was buried in a Jewish consecrated grave in the grounds of the Baptist oratory, next to his family weekend home in Suffolk."

Some key papers

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Awards and honours

He was elected a Fellow of the Royal Society (FRS) in 1993, “a source of particular pride for his father and a very rare concurrence of father and son as Fellows.” and was awarded their GlaxoSmithKline Prize in 2003. He also received the

Novartis Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...

medal in 2002 and delivered the Novartis medal lecture, entitled "Antibodies: a Paradigm for the Evolution of Molecular Recognition" on 9 April 2002 at

Heriot-Watt University Heriot-Watt University ( gd, Oilthigh Heriot-Watt) is a public research university based in Edinburgh, Scotland. It was established in 1821 as the School of Arts of Edinburgh, the world's first mechanics' institute, and subsequently granted univ ...

, Edinburgh. In 2013 Neuberger was appointed a Foreign Associate of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

References

{{DEFAULTSORT:Neuberger, Michael 1953 births 2013 deaths People educated at Westminster School, London Alumni of Trinity College, Cambridge Alumni of Imperial College London Fellows of Trinity College, Cambridge Fellows of the Royal Society Members of the European Molecular Biology Organization Foreign associates of the National Academy of Sciences British biochemists English Jews Jewish scientists

Michael Michael may refer to: People * Michael (given name), a given name * Michael (surname), including a list of people with the surname Michael Given name "Michael" * Michael (archangel), ''first'' of God's archangels in the Jewish, Christian an ...

English people of German-Jewish descent Deaths from multiple myeloma