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César Milstein
César Milstein, CH, FRS (8 October 1927 – 24 March 2002) was an Argentine biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler for developing the hybridoma technique for the production of monoclonal antibodies. Biography Milstein was born in Bahía Blanca, Argentina. His parents were Máxima (Vapniarsky) and Lázaro Milstein, a Jewish Ukrainian immigrant. He graduated from the University of Buenos Aires and obtained a PhD under Professor Stoppani (Professor of Biochemistry). Thereafter, he was a member of the Medical Research Council Laboratory of Molecular Biology, Cambridge, England, and held dual Argentine and British citizenship. In 1956, he received an award from the Sociedad Bioquímica Argentina for his work on kinetic studies with the enzyme aldehyde dehydrogenase. In 1958, funded by the British Council, he joined the Biochemistry Department at the University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bahía Blanca
Bahía Blanca (; English: White Bay) is a city in the southwest of the provinces of Argentina, province of Buenos Aires Province, Buenos Aires, Argentina, by the Atlantic Ocean, and is the seat of government of the Bahía Blanca Partido. It had 301,572 inhabitants according to the . It is the principal city in the Greater Bahía Blanca urban agglomeration. The city has an important seaport with a depth of 45 feet (15 m), kept constant upstream almost all along the length of the bay, where the Napostá Stream drains. ''Bahía Blanca'' means "White Bay". The name is due to the typical color of the salt covering the soil surrounding the shores. The bay (which is an estuary) was seen by Ferdinand Magellan during his first circumnavigation of the world on the order of Charles I of Spain in 1520, looking for a canal connecting the Atlantic to the Pacific Ocean along the coasts of South America. Foundation The city was founded as a fortress on 11th April 1828 by Colonel Ramón Estomba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Copley Medal
The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is the oldest Royal Society medal awarded and the oldest surviving scientific award in the world, having first been given in 1731 to Stephen Gray (scientist), Stephen Gray, for "his new Electrical Experiments: – as an encouragement to him for the readiness he has always shown in obliging the Society with his discoveries and improvements in this part of Natural Knowledge". __TOC__ History The medal was created following a donation of Pound sterling, £100 to be used for carrying out experiments by Sir Godfrey Copley, 2nd Baronet, Sir Godfrey Copley, for which the interest on the amount was used for several years. The conditions for the medal have been changed several times; in 1736, it was suggested that "a medal or other honorary prize s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nederlands Tijdschrift Voor Geneeskunde
The ''Nederlands Tijdschrift voor Geneeskunde'' (NTvG; English: ''Dutch Journal of Medicine'') is the main medical journal in the Netherlands, appearing weekly. Established in 1857, it is one of the world's oldest journals. Its publication language is exclusively Dutch. The journal is published and supported by the Vereniging NTvG (English: Society NTvG), which is currently composed of 209 medical scientists. The current editor-in-chief is Yolanda van der Graaf. The Journal's headquarter is situated in Amsterdam, the Netherlands. From early on, the objective was to create an overarching and all-encompassing journal for medical professionals to exchange insights, knowledge and opinion, and to guarantee consistent progress throughout the country. At present, the main sections include: News, Opinion, Research, Clinical Practice, Perspective. Nowadays, the NTvG focuses on reviews and commentaries of research articles which are often published in English. Further, it continues to produc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. ''The Lancet'' has been owned by Elsevier since 1991, and its editor-in-chief since 1995 has been Richard Horton. The journal has editorial offices in London, New York City, and Beijing. History ''The Lancet'' was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). Members of the Wakley family retained editorship of the journal until 1908. In 1921, ''The Lancet'' was acquired by Hodder & Stoughton. Elsevier acquired ''The Lancet'' from Hodder & Stoughton in 1991. Impact According to the ''Journal Citation Reports'', the journal has a 202 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hybridoma
Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies). This process starts by injecting a mouse (or other mammal) with an antigen that provokes an immune response. A type of white blood cell, the B cell, produces antibodies that bind to the injected antigen. These antibody producing B-cells are then harvested from the mouse and, in turn, fused with immortal B cell cancer cells, a myeloma, to produce a hybrid cell line called a hybridoma, which has both the antibody-producing ability of the B-cell and the longevity and reproductivity of the myeloma. The hybridomas can be grown in culture, each culture starting with one viable hybridoma cell, producing cultures each of which consists of genetically identical hybridomas which produce one antibody per culture (monoclonal) rather than mixtures of different antibodies (polyclonal). The myeloma cell line that is used in this process is selected for its ability to grow i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Georges J
Georges may refer to: Places *Georges River, New South Wales, Australia *Georges Quay (Dublin) *Georges Township, Fayette County, Pennsylvania Other uses *Georges (name) * ''Georges'' (novel), a novel by Alexandre Dumas * "Georges" (song), a 1977 song originally recorded by Pat Simon and covered by Sylvie Vartan *Georges (store), a department store in Melbourne, Australia from 1880 to 1995 * Georges (''Green Card'' character) People with the surname * Eugenia Georges, American anthropologist *Karl Ernst Georges (1806–1895), German classical philologist and lexicographer, known for his edition of Latin-German dictionaries. See also *École secondaire Georges-P.-Vanier, a high school in Hamilton, Ontario, Canada *École secondaire Georges-Vanier in Laval, Quebec, Canada * French cruiser ''Georges Leygues'', commissioned in 1937 * French frigate ''Georges Leygues'' (D640), commissioned in 1979 *George (other) *Georges Creek (other) *Georges Creek Coal and Iron Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Niels Kaj Jerne
Niels Kaj Jerne, FRS (23 December 1911 – 7 October 1994) was a Danish immunologist. He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies". Jerne is known for three significant ideas. Firstly, instead of the body producing antibodies in response to an antigen, Jerne postulated that the immune system already has the specific antibodies it needs to fight antigens. Secondly, it was known that the immune system learns to be tolerant to the individual's own self. Jerne postulated that this learning takes place in the thymus. Thirdly, it was known that T cells and B cells communicate with each other. Jerne's network theory proposed that the active sites of antibodies are attracted to both specific antigens (idiotypes) and to other antibodies that bind to the same ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Current Biology
''Current Biology'' is a biweekly peer-reviewed scientific journal that covers all areas of biology, especially molecular biology, cell biology, genetics, neurobiology, ecology, and evolutionary biology. The journal includes research articles, various types of review articles, as well as an editorial magazine section. The journal was established in 1991 by the Current Science group, acquired by Elsevier in 1998 and has since 2001 been part of Cell Press, a subdivision of Elsevier. According to ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 10.834. It was categorized as a "high impact journal" by the Superfund Research Program. References External links * Biology journals English-language journals Cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Immunology
''Nature Immunology'' is a monthly peer-reviewed scientific journal covering immunology. It was established in 2000, as an expansion of the ''Nature'' family of journals. The editor-in-chief is Jamie D. K. Wilson. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 31.250, ranking it 4th out of 161 journals in the category "Immunology". References External links *{{Official website, http://www.nature.com/ni/index.html Publications established in 2000 Immunology journals Nature Research academic journals Monthly journals English-language journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few varia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
