Michael J. Krische ( FRSC, FAAAS; born September 16, 1966) is an American chemist and Robert A. Welch Chair in Science at the Department of Chemistry,

University of Texas at Austin The University of Texas at Austin (UT Austin, UT, or Texas) is a public research university in Austin, Texas. It was founded in 1883 and is the oldest institution in the University of Texas System. With 40,916 undergraduate students, 11,075 ...

. Krische has pioneered a broad, new family of catalytic C-C bond formations that occur through the addition or redistribution of hydrogen. These processes merge the characteristics of catalytic hydrogenation and carbonyl addition, contributing to a departure from the use of stoichiometric organometallic reagents in chemical synthesis.

Life

Krische was born in 1966 in

Burlingame, California Burlingame () is a city in San Mateo County, California. It is located on the San Francisco Peninsula and has a significant shoreline on San Francisco Bay. The city is named after diplomat Anson Burlingame and is known for its numerous eucalyp ...

, a city on the San Francisco peninsula. He is the son of Joseph Krische, a

Gottschee Gottschee (, sl, Kočevsko) refers to a former German-speaking region in Carniola, a crownland of the Habsburg monarchy, Habsburg Empire, part of the historical and traditional region of Lower Carniola, now in Slovenia. The region has been a coun ...

German who immigrated to the USA in 1952 after a 7-year period in the Kapfenberg displaced persons camp following WWII, and Corliss Krische (née Heimburger), who is a native of

Urbana, Illinois Urbana ( ) is a city in and the county seat of Champaign County, Illinois, United States. As of the 2020 census, Urbana had a population of 38,336. As of the 2010 United States Census, Urbana is the List of municipalities in Illinois, 38th-most pop ...

Education and career

Michael J. Krische obtained a B.S. degree in chemistry from the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

(1986–1989), where he performed research with

Henry Rapoport Henry Rapoport (November 16, 1918 – March 6, 2002) was an internationally renowned organic chemistry, organic chemist and Professor of Chemistry at the University of California, Berkeley. He is widely recognized for his work in the development ...

. After one year abroad as a

Fulbright Fellow The Fulbright Program, including the Fulbright–Hays Program, is one of several United States Cultural Exchange Programs with the goal of improving intercultural relations, cultural diplomacy, and intercultural competence between the people of ...

between 1989 and 1990 at

University of Helsinki The University of Helsinki ( fi, Helsingin yliopisto, sv, Helsingfors universitet, abbreviated UH) is a public research university located in Helsinki, Finland since 1829, but founded in the city of Turku (in Swedish ''Åbo'') in 1640 as the ...

, he initiated doctoral studies in chemistry in 1990 at

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

with

Barry Trost Barry M. Trost (born June 13, 1941, in Philadelphia) is an American chemist who is the Job and Gertrud Tamaki Professor Emeritus in the School of Humanities and Sciences at Stanford University. The Tsuji-Trost reaction and the Trost ligand are ...

as a Veatch Graduate Fellow. Following receipt of his Ph.D. degree (1996), he joined the laboratory of Nobel Laureate

Jean-Marie Lehn Jean-Marie Lehn (born 30 September 1939) is a French chemist. He received the Nobel Prize in Chemistry together with Donald Cram and Charles Pedersen in 1987 for his synthesis of cryptands. Lehn was an early innovator in the field of supramolec ...

at the

Universite Louis Pasteur Louis Pasteur University (''Université Louis-Pasteur''), also known as Strasbourg I or ULP was a large university in Strasbourg, Alsace, France. As of 15 January 2007, there were 18,847 students enrolled at the university, including around 3, ...

(now University of Strasbourg) as an NIH Post-Doctoral Fellow. In 1999, he joined the faculty at the University of Texas at Austin. Krische was promoted directly to the rank of full professor (2004), and shortly thereafter appointed the Robert A. Welch Chair in Science (2007).

Research

Stereo- and site-selective methods for the byproduct-free modification of unprotected organic compounds that occur through the addition or redistribution of hydrogen are natural endpoints in the advancement of methods for efficient, green chemical synthesis. Krische has demonstrated hydrogenation or transfer hydrogenation of π-unsaturated reactants in the presence of C=X (X = O, NR) bonds delivers products of carbonyl or imine addition. In related hydrogen auto-transfer reactions, alcohols served dually as reductants and carbonyl proelectrophiles, enabling direct, stereo- and site-selective conversion of lower alcohols to higher alcohols. The

Krische allylation The Krische allylation involves the enantioselective iridium-catalyzed addition of an allyl group to an aldehyde or an alcohol, resulting in the formation of a secondary homoallylic alcohol. The mechanism of the Krische allylation involves primar ...

exemplifies the latter class of C-C coupling. Application of these methods in natural product total synthesis have been shown to increase step-economy. For example, a concise total synthesis of swinholide A was achieved using diverse hydrogen-mediated C-C couplings.

Major awards

* NSF-CAREER Award (2000) * Cottrell Scholar Award (2002) * Eli Lilly Granteeship for Untenured Faculty (2002) * Frasch Award in Chemistry (2002) * Dreyfus Teacher-Scholar Award (2003) * Alfred P. Sloan Fellowship (2003) * Johnson & Johnson Focused Giving Award (2005) * Solvias Ligand Prize (2006) * Presidential Green Chemistry Award (2007) * ACS Corey Award (2007) * Dowpharma Prize (2007) * Tetrahedron Young Investigator Award (2009) * Humboldt Senior Research Award (2009–2011) * Mukaiyama Award (2010) * Glaxo-Smith-Kline Scholar Award (2011) * ACS Cope Scholar Award (2012) * Japanese Society for the Promotion of Science Fellow (2013) * Royal Society of Chemistry, Pedlar Award (2015) * American Association for the Advancement of Science Fellow (2017) *ACS Award for Creative Work in Synthetic Organic Chemistry (2020)

References

External links

Krische Group Website
{{DEFAULTSORT:Krische, Michael J. 1966 births Living people People from Burlingame, California 20th-century American chemists 21st-century American chemists American people of German descent University of California, Berkeley alumni Humboldt Research Award recipients Fellows of the American Association for the Advancement of Science Sloan Research Fellows University of Texas at Austin faculty Stanford University alumni