Mavacoxib (trade name Trocoxil) is a
veterinary drug
An animal drug (also veterinary drug) refers to a pharmaceutical drug, drug intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in animals.
Regulation United States
The U.S. Food and Drug Administration (FDA) ...
used to treat pain and inflammation in dogs with degenerative joint
disease. It acts as a
COX-2 inhibitor
COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration and i ...
.
Mavacoxib, along with other COX-2 selective inhibitors,
celecoxib
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankyl ...
,
valdecoxib
Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. It was patented in 1995.
V ...
, and
parecoxib
Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved through much of Europe for short term perioperative p ...
, were discovered by a team at the
Searle Searle may refer to:
__NOTOC__ Persons
* Searle (surname)
* J. Searle Dawley (1877–1949), American film director, producer, screenwriter, stage actor and playwright
* Searle Turton (born 1979), Canadian politician
Places
* Serle, a comune in Lomb ...
division of
Monsanto
The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup, a glyphosate-based herbicide, developed in th ...
led by
John Talley.
References
COX-2 inhibitors
Nonsteroidal anti-inflammatory drugs
Fluoroarenes
Sulfonamides
Pyrazoles
Trifluoromethyl compounds
{{musculoskeletal-drug-stub