Marina R. Picciotto
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Marina Rachel Picciotto (born June 22, 1963) is an American
neuroscientist A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, Biological neural network, n ...
known for her work on the role of
nicotine Nicotine is a natural product, naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and ''Duboisia hopwoodii'') and is widely used recreational drug use, recreationally as a stimulant and anxiolytic. As ...
in
addiction Addiction is a neuropsychological disorder characterized by a persistent and intense urge to engage in certain behaviors, one of which is the usage of a drug, despite substantial harm and other negative consequences. Repetitive drug use o ...
, memory, and reward behaviors. She is the Charles B. G. Murphy Professor of Psychiatry and
professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who pr ...
in the Child Study Center and the Departments of Neuroscience and of Pharmacology at the
Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...
School of Medicine. Since 2015, she has been
editor-in-chief An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies. The highest-ranking editor of a publication may also be titled editor, managing ...
of the ''
Journal of Neuroscience A journal, from the Old French ''journal'' (meaning "daily"), may refer to: *Bullet journal, a method of personal organization *Diary, a record of what happened over the course of a day or other period *Daybook, also known as a general journal, a ...
''.


Education and early life

Born in
Bloomington, Indiana Bloomington is a city in and the county seat of Monroe County, Indiana, Monroe County in the central region of the U.S. state of Indiana. It is the List of municipalities in Indiana, seventh-largest city in Indiana and the fourth-largest outside ...
on June 22, 1963, Picciotto moved to
New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...
as a young child and graduated from
Hunter College High School Hunter College High School is a secondary school located in the Carnegie Hill neighborhood on the Upper East Side of Manhattan. It is administered by Hunter College of the City University of New York (CUNY). Hunter is publicly funded, and there i ...
in 1981. Picciotto received her
B.S. A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of ...
in biology from
Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
in 1985, and her
Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...
in 1992 from
Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...
. She carried out post-doctoral work at the
Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines f ...
in
Paris Paris () is the capital and most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), making it the 30th most densely populated city in the world in 2020. S ...
from 1992-1995.


Scientific career

Picciotto began her career in neuroscience as an undergraduate researcher at
Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
, where she worked with Richard Scheller. There she discovered that the
FMRFamide FMRFamide (H-Phe-Met-Arg-Phe-NH2) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam (''Mercenaria mercenaria''), it is thought to play a ...
gene gives rise to multiple copies of the neuropeptide. She went on to PhD work with
Paul Greengard Paul Greengard (December 11, 1925 – April 13, 2019) was an American neuroscientist best known for his work on the molecular and cellular function of neurons. In 2000, Greengard, Arvid Carlsson and Eric Kandel were awarded the Nobel Prize for Ph ...
at
Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...
where she cloned the gene for calcium/calmodulin-dependent protein kinase 1. As a
Human Frontier Science Program } The International Human Frontier Science Program Organization (HFSPO) is a non-profit organization, based in Strasbourg, France, that funds basic research in life sciences. The organization implements the Human Frontier Science Program (HFSP) and ...
postdoctoral fellow with
Jean-Pierre Changeux Jean-Pierre Changeux (; born 6 April 1936) is a French neuroscientist known for his research in several fields of biology, from the structure and function of proteins (with a focus on the allosteric proteins), to the early development of the ner ...
at the
Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines f ...
in
Paris Paris () is the capital and most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), making it the 30th most densely populated city in the world in 2020. S ...
, Picciotto produced the first mouse knock-out lacking a nicotinic receptor subunit. She returned to the United States in 1995 to join the
Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...
faculty as an
assistant professor Assistant Professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States and Canada. Overview This position is generally taken after earning a doctoral degree and general ...
and rising through the ranks to become the Charles B.G. Murphy Professor in Psychiatry in 2008. Her group is known for its discoveries in nicotine addiction and brain circuits. Recent work from Picciotto showed that pre-natal exposure to nicotine has profound effects on adult behavior. In press interviews, she has expressed concerns about the use of e-cigarettes and low-dose nicotine cigarettes.


Editorial

In 2015, Picciotto was named editor-in-chief of ''
The Journal of Neuroscience ''The Journal of Neuroscience'' is a weekly peer-reviewed scientific journal published by the Society for Neuroscience. It covers empirical research on all aspects of neuroscience. Its editor-in-chief is Marina Picciotto (Yale University). Accordin ...
''. Since taking over leadership at the journal, she has instituted a number of changes including eliminating submission fees for
Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well kn ...
members and restoring the ability of authors to publish supplementary data alongside their papers. Picciotto has also instituted new controls on statistical analysis and experimental design reporting. In a move to support pre-print publishing, Picciotto added ''The Journal of Neuroscience'' to the list of journals that will accept submissions directly from
bioRxiv bioRxiv (pronounced "bio-archive") is an open access preprint repository for the biological sciences co-founded by John Inglis and Richard Sever in November 2013. It is hosted by the Cold Spring Harbor Laboratory (CSHL). As preprints, papers h ...
. She has also started initiatives on social media to thank scientists who participate in
peer review Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review ...
at the journal.


Awards

President
Bill Clinton William Jefferson Clinton ( né Blythe III; born August 19, 1946) is an American politician who served as the 42nd president of the United States from 1993 to 2001. He previously served as governor of Arkansas from 1979 to 1981 and agai ...
presented Picciotto with the
Presidential Early Career Award for Scientists and Engineers The Presidential Early Career Award for Scientists and Engineers (PECASE) is the highest honor bestowed by the United States government on outstanding scientists and engineers in the early stages of their independent research careers. The White ...
at the
White House The White House is the official residence and workplace of the president of the United States. It is located at 1600 Pennsylvania Avenue NW in Washington, D.C., and has been the residence of every U.S. president since John Adams in 1800. ...
in 2000. She received the Jacob P. Waletzky Memorial Award for Innovative Research in Drug Addiction and Alcohol Research from The
Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well kn ...
in 2007. Picciotto was elected as an AAAS fellow of the
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
in 2014, and was elected to the
National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...
in 2012. In 2019, Picciotto was among 11 scientists awarded the National Institutes of Health’s Pioneer Award. That same year, she was awarded the Bernice Grafstein award for advancing the careers of women in neuroscience.


Selected publications

* * * *


References


External links

* {{DEFAULTSORT:Picciotto, Marina 1963 births Living people Members of the National Academy of Medicine Yale University faculty American women neuroscientists American neuroscientists Rockefeller University alumni Stanford University alumni Hunter College High School alumni American women scientists Scientists from New York (state)